Microsatellites are highly abundant short repetitive sequences found in the genomes across
different species. They have gained increasing interest in recent years because length …

Mismatch repair (MMR)-deficient cancers accumulate multiple insertion/deletion mutations
at coding microsatellites (cMS), which give rise to frameshift peptide neoantigens. The high …

Besides being expressed on professional antigen-presenting cells, HLA class II antigens are
expressed on various tumors of non-lymphoid origin, including a subset of colorectal …

Like many other types of cancer, colorectal cancer (CRC) develops through multiple
pathways of carcinogenesis. This is also true for colorectal carcinogenesis in Lynch …

Introduction Lynch syndrome is a multi-tumor syndrome characterized by mismatch repair
deficiency (MMR-d), microsatellite instability (MSI), and increased tumor-infiltrating …

Glycosyl epitopes have been identified as tumor-specific markers in colorectal tumors and
various lines of evidence indicate the significance of altered synthesis, transport, and …

Cells are the basic structural and functional units of all living organisms. The estimations
about the total cell count of a human body vary widely; a number as large as 1014 seems …

Background: Microsatellite instability (MSI) is a phenotypic characteristic of tumors with
biallelic inactivation of mismatch repair genes, such as MSH2 or MLH1, and contributes to …

Krebs ist weltweit eine der häufigsten krankheitsbedingten Todesursachen. In den letzten
Jahren sind große Datenmengen zur Krebsgenetik und zu molekularen Eigenschaften …

The clinical success of immunotherapies demonstrates the importance of the immune
system in tumour control, but the response rates remain low and many biological …