To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of
attention in recent years in particular with the advent of clinical successes achieved by …

The tumor microenvironment (TME) has been identified as one of the driving factors of tumor
progression and invasion. Within this microenvironment, cancer‐associated fibroblasts …

Simple Summary As our knowledge of cancer as a complex organ comprising tumor cells as
well as surrounding cells within the microenvironment continues to grow, it is imperative to …

Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

Simple Summary Reprogramming metabolism is a hallmark of cancer. Warburg's effect,
defined as increased aerobic glycolysis at the expense of mitochondrial respiration in …

Simple Summary Tumor microenvironment is a major contributor to tumor growth, metastasis
and resistance to therapy. It consists of many cancer-associated fibroblasts (CAFs), which …

Exercise prevents cancer incidence and recurrence, yet the underlying mechanism behind
this relationship remains mostly unknown. Here we report that exercise induces the …

Tissue-resident fibroblasts are mesenchymal cells which control the structural integrity of the
extracellular matrix (ECM). Fibroblasts possess a remarkable plasticity to allow them to …

Immunometabolism is an emerging discipline in cancer immunotherapy. Tumor tissues are
heterogeneous and influenced by metabolic reprogramming of the tumor immune …

Current cancer therapeutic strategies are generally not sufficient to eradicate malignancy, as
cancer stroma cells contribute to tumor evasion and therapeutic resistance. Cancer …