Heart failure (HF) is a state of chronic deterioration of oxidative mechanisms due to
enhanced oxidative stress and consequent subcellular alterations. In this condition, oxidant …

Effective treatment for heart failure with preserved ejection fraction (HFpEF) is an unmet
need in cardiovascular medicine. The pathophysiological drivers of HFpEF are complex …

Significance: Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease
characterized by left ventricular hypertrophy, diastolic dysfunction, and myocardial disarray …

Although there have been significant advances in the therapy of heart failure in recent
decades, such as the introduction of beta-blockers and antagonists of the renin–angiotensin …

Mitochondrial dysfunction plays a critical role in the development of cardiac hypertrophy and
heart failure. So mitochondria are emerging as one of the important druggable targets in the …

Cardiovascular disease (CVD) prevalence, pathogenesis, and manifestation is differentially
influenced by biological sex. Berry polyphenols target several signaling pathways pertinent …

Background Hyperglycemia-induced oxidative stress plays a central role in the development
of diabetic myocardial complications. Adiponectin (APN), an adipokine with anti-diabetic and …

Heart failure is a leading cause of morbidity and mortality worldwide, currently affecting 5
million Americans. A syndrome defined on clinical terms, heart failure is the end result of …

Xanthine oxidoreductase (XOR) is an enzyme responsible for purine degradation, reactive
oxygen species production, and adipogenesis. XOR gene-disrupted (XOR−/−) mice …

The present study evaluated the antihypertrophic potential of the ethanolic extract of
Boerhaavia diffusa (BDE), a well-known edible cardiotonic plant reported in Ayurveda …