[HTML][HTML] Liquid biopsy for infectious diseases: a focus on microbial cell-free DNA sequencing

D Han, R Li, J Shi, P Tan, R Zhang, J Li - Theranostics, 2020 - ncbi.nlm.nih.gov
Metagenomic next-generation sequencing (mNGS) of microbial cell-free DNA (mcfDNA
sequencing) is becoming an attractive diagnostic modality for infectious diseases, allowing …

[HTML][HTML] Exploring the utility of multiplex infectious disease panel testing for diagnosis of infection in different body sites: a joint report of the Association for Molecular …

MA Lewinski, K Alby, NE Babady, SM Butler-Wu… - The Journal of Molecular …, 2023 - Elsevier
The utilization of clinical molecular diagnostic methods for detecting microbial pathogens
continues to expand and, in some cases, supplant conventional identification methods in …

Clinical evaluation of an improved metagenomic next-generation sequencing test for the diagnosis of bloodstream infections

C Jing, H Chen, Y Liang, Y Zhong, Q Wang… - Clinical …, 2021 - academic.oup.com
Background Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA
has emerged as a promising diagnostic technology for bloodstream infections. However, a …

Liquid biopsy for invasive mold infections in hematopoietic cell transplant recipients with pneumonia through next-generation sequencing of microbial cell-free DNA in …

JA Hill, SC Dalai, DK Hong, AA Ahmed… - Clinical Infectious …, 2021 - academic.oup.com
Background Noninvasive diagnostic options are limited for invasive mold infections (IMIs).
We evaluated the performance of a plasma microbial cell-free DNA sequencing (mcfDNA …

Value of CRP, PCT, and NLR in prediction of severity and prognosis of patients with bloodstream infections and sepsis

P Liang, F Yu - Frontiers in Surgery, 2022 - frontiersin.org
Objective To investigate the value of C-reactive protein (CRP), procalcitonin (PCT), and
neutrophil to lymphocyte ratio (NLR) in assessing the severity of disease in patients with …

Plasma metagenomic next-generation sequencing assay for identifying pathogens: a retrospective review of test utilization in a large children's hospital

DT Niles, DSS Wijetunge, DL Palazzi… - Journal of clinical …, 2020 - Am Soc Microbiol
Plasma metagenomic next-generation sequencing (mNGS) is a new diagnostic method
used to potentially identify multiple pathogens with a single DNA-based diagnostic test. The …

Diagnostic value of metagenomic next-generation sequencing in sepsis and bloodstream infection

C Qin, S Zhang, Y Zhao, X Ding, F Yang… - Frontiers in Cellular and …, 2023 - frontiersin.org
Objective To evaluate the diagnostic value of metagenomic next-generation sequencing
(mNGS) in sepsis and bloodstream infection (BSI). Methods A retrospective analysis of …

Clinical metagenomic sequencing of plasma microbial cell-free DNA for febrile neutropenia in patients with acute leukaemia

S Feng, G Rao, X Wei, R Fu, M Hou, Y Song… - Clinical Microbiology …, 2024 - Elsevier
Objectives To evaluate the diagnostic performance and clinical impact of metagenomic next-
generation sequencing (mNGS) of plasma microbial cell-free DNA (mcfDNA) in febrile …

Metagenomics by next-generation sequencing (mNGS) in the etiological characterization of neonatal and pediatric sepsis: a systematic review

S Agudelo-Pérez, J Fernández-Sarmiento… - Frontiers in …, 2023 - frontiersin.org
Introduction Pediatric and neonatal sepsis is one of the main causes of mortality and
morbidity in these age groups. Accurate and early etiological identification is essential for …

Metagenomic next-generation sequencing in detecting pathogens in pediatric oncology patients with suspected bloodstream infections

J Wu, W Song, H Yan, C Luo, W Hu, L Xie, N Shen… - Pediatric …, 2024 - nature.com
Background Studies on mNGS application in pediatric oncology patients, who are at high
risk of infection, are quite limited. Methods From March 2020 to June 2022, a total of 224 …