Advances in tissue engineering through stem cell‐based co‐culture
NK Paschos, WE Brown… - Journal of tissue …, 2015 - Wiley Online Library
Stem cells are the future in tissue engineering and regeneration. In a co‐culture, stem cells
not only provide a target cell source with multipotent differentiation capacity, but can also act …
not only provide a target cell source with multipotent differentiation capacity, but can also act …
Myocyte death, growth, and regeneration in cardiac hypertrophy and failure
B Nadal-Ginard, J Kajstura, A Leri… - Circulation research, 2003 - Am Heart Assoc
The accepted paradigm considers the adult mammalian heart as a postmitotic organ, which
possesses a relatively constant number of myocytes from shortly after birth to adulthood and …
possesses a relatively constant number of myocytes from shortly after birth to adulthood and …
[HTML][HTML] Adult cardiac stem cells are multipotent and support myocardial regeneration
AP Beltrami, L Barlucchi, D Torella, M Baker, F Limana… - cell, 2003 - cell.com
The notion of the adult heart as terminally differentiated organ without self-renewal potential
has been undermined by the existence of a subpopulation of replicating myocytes in normal …
has been undermined by the existence of a subpopulation of replicating myocytes in normal …
Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
Y Zhao, E Samal, D Srivastava - Nature, 2005 - nature.com
Gradients of signalling and transcription factors govern many aspects of embryogenesis,
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
KL Laugwitz, A Moretti, J Lam, P Gruber, Y Chen… - Nature, 2005 - nature.com
The purification, renewal and differentiation of native cardiac progenitors would form a
mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their …
mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their …
Phosphoinositide 3-kinase (p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
JR McMullen, T Shioi, L Zhang… - Proceedings of the …, 2003 - National Acad Sciences
An unresolved question in cardiac biology is whether distinct signaling pathways are
responsible for the development of pathological and physiological cardiac hypertrophy in …
responsible for the development of pathological and physiological cardiac hypertrophy in …
Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression
To determine whether cellular aging leads to a cardiomyopathy and heart failure, markers of
cellular senescence, cell death, telomerase activity, telomere integrity, and cell regeneration …
cellular senescence, cell death, telomerase activity, telomere integrity, and cell regeneration …
Cardiac stem cells and mechanisms of myocardial regeneration
A Leri, JAN Kajstura, P Anversa - Physiological reviews, 2005 - journals.physiology.org
This review discusses current understanding of the role that endogenous and exogenous
progenitor cells may have in the treatment of the diseased heart. In the last several years, a …
progenitor cells may have in the treatment of the diseased heart. In the last several years, a …
Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts
In the pathogenesis of dilated cardiomyopathy, cytoskeletal proteins play an important role.
In this study, we analyzed titin expression in left ventricles of 19 control human donors and 9 …
In this study, we analyzed titin expression in left ventricles of 19 control human donors and 9 …
[HTML][HTML] ASF/SF2-regulated CaMKIIδ alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle
X Xu, D Yang, JH Ding, W Wang, PH Chu, ND Dalton… - Cell, 2005 - cell.com
The transition from juvenile to adult life is accompanied by programmed remodeling in many
tissues and organs, which is key for organisms to adapt to the demand of the environment …
tissues and organs, which is key for organisms to adapt to the demand of the environment …