Stem cells are the future in tissue engineering and regeneration. In a co‐culture, stem cells
not only provide a target cell source with multipotent differentiation capacity, but can also act …

The accepted paradigm considers the adult mammalian heart as a postmitotic organ, which
possesses a relatively constant number of myocytes from shortly after birth to adulthood and …

The notion of the adult heart as terminally differentiated organ without self-renewal potential
has been undermined by the existence of a subpopulation of replicating myocytes in normal …

Gradients of signalling and transcription factors govern many aspects of embryogenesis,
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …

The purification, renewal and differentiation of native cardiac progenitors would form a
mechanistic underpinning for unravelling steps for cardiac cell lineage formation, and their …

An unresolved question in cardiac biology is whether distinct signaling pathways are
responsible for the development of pathological and physiological cardiac hypertrophy in …

To determine whether cellular aging leads to a cardiomyopathy and heart failure, markers of
cellular senescence, cell death, telomerase activity, telomere integrity, and cell regeneration …

This review discusses current understanding of the role that endogenous and exogenous
progenitor cells may have in the treatment of the diseased heart. In the last several years, a …

In the pathogenesis of dilated cardiomyopathy, cytoskeletal proteins play an important role.
In this study, we analyzed titin expression in left ventricles of 19 control human donors and 9 …

The transition from juvenile to adult life is accompanied by programmed remodeling in many
tissues and organs, which is key for organisms to adapt to the demand of the environment …