Type I interferons (IFNs) are a family of cytokines involved in the defense against viral
infections that play a key role in the activation of both the innate and adaptive immune …

The recent epidemic of the arthritogenic alphavirus, chikungunya virus (CHIKV) has
prompted a quest to understand the correlates of protection against virus and disease in …

The contribution of dyslipidemia and inflammation in atherosclerosis is well established.
Along with effective lipid-lowering treatments, the recent success of clinical trials with anti …

Microbes activate pattern recognition receptors to initiate adaptive immunity. T cells affect
early innate inflammatory responses to viral infection, but both activation and suppression …

Background Nucleic acids are potent stimulators of type I interferon (IFN-I) and antiviral
defense, but may also promote pathological inflammation. A range of diseases are …

Agonists for TLR9 and Stimulator of IFN Gene (STING) act as vaccine adjuvants that induce
type‐1 immune responses. However, currently available CpG oligodeoxynucleotide …

Whether and how an acute immune challenge may affect DNA Damage Response (DDR) is
unknown. By studying vaccinations against Influenza and SARS-CoV-2 (mRNA-based) we …

Neutralizing antibodies have been thought to be required for protection against acutely
cytopathic viruses, such as the neurotropic vesicular stomatitis virus (VSV). Utilizing mice …

Virus-like particles (VLP) spontaneously assemble from viral structural proteins. They are
naturally biocompatible and non-infectious. VLP can serve as a platform for many potential …

Respiratory viral infections represent the leading cause of hospitalization in infants and
young children worldwide, and the second cause of infant mortality. 1 Of all Disclosures: A …