Solidification of nanosuspensions for the production of solid oral dosage forms and inhalable dry powders

M Malamatari, S Somavarapu, KMG Taylor… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Nanosuspensions combine the advantages of nanotherapeutics (eg increased
dissolution rate and saturation solubility) with ease of commercialisation. Transformation of …

iBCS: 1. Principles and framework of an inhalation-based biopharmaceutics classification system

JE Hastedt, P Bäckman, A Cabal, A Clark… - Molecular …, 2022 - ACS Publications
For oral drugs, the formulator and discovery chemist have a tool available to them that can
be used to navigate the risks associated with the selection and development of immediate …

Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products

SP Velaga, J Djuris, S Cvijic, S Rozou, P Russo… - European Journal of …, 2018 - Elsevier
In vitro dissolution testing is routinely used in the development of pharmaceutical products.
Whilst the dissolution testing methods are well established and standardized for oral dosage …

Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs

S Radivojev, S Zellnitz, A Paudel, E Froehlich - International journal of …, 2019 - Elsevier
Inhalation is the preferred route for the treatment of lung diseases. More recently, also
formulations for systemic treatment have been developed. For efficient development of …

[HTML][HTML] Impact of simulated lung fluid components on the solubility of inhaled drugs and predicted in vivo performance

S Radivojev, G Luschin-Ebengreuth, JT Pinto… - International Journal of …, 2021 - Elsevier
Orally inhaled products (OIPs) are gaining increased attention, as pulmonary delivery is a
preferred route for the treatment of various diseases. Yet, the field of inhalation …

In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols

MYT Chow, W Tai, RYK Chang, HK Chan… - Advanced Drug Delivery …, 2021 - Elsevier
In vitro-in vivo correlation is the establishment of a predictive relationship between in vitro
and in vivo data. In the context of cascade impactor results of orally inhaled pharmaceutical …

Dissolution and biological assessment of cancer-targeting nano-zif-8 in zebrafish embryos

NAMA Kamal, E Abdulmalek, S Fakurazi… - ACS Biomaterials …, 2022 - ACS Publications
Cancer-targeting nanotherapeutics offer promising opportunities for selective delivery of
cytotoxic chemotherapeutics to cancer cells. However, the understanding of dissolution …

Elucidation of the effect of added fines on the performance of dry powder inhalation formulations

M Stankovic-Brandl, S Radivojev, P Sailer… - International Journal of …, 2022 - Elsevier
Dry powder inhalers (DPIs) are regularly used to treat respiratory diseases. Adding extrinsic
fine excipient particles to the blend of active pharmaceutical ingredient (API) and carrier is …

[HTML][HTML] Particulate bioaerogels for respiratory drug delivery

HY Li, C Makatsoris, B Forbes - Journal of Controlled Release, 2024 - Elsevier
The bioaerogel microparticles have been recently developed for respiratory drug delivery
and attract fast increasing interests. These highly porous microparticles have ultralow …

Inhalable microparticles containing terbinafine for management of pulmonary fungal infections: Spray drying process engineering using lactose vs. mannitol as …

K Almansour, IM Alfagih, R Ali, MMA Elsayed - Journal of Drug Delivery …, 2020 - Elsevier
Terbinafine is a broad-spectrum antifungal agent with potential therapeutic value in
management of pulmonary aspergillosis. To this end, dry powder inhalation formulations of …