[HTML][HTML] MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment

J Xu, Y Sun, W Fu, S Fu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract Myc target 1 (MYCT1), located at 6q25. 2, is a crucial player in cancer development.
While widely distributed in cells, its subcellular localization varies across different cancer …

[HTML][HTML] Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes

MT Teh, E Gemenetzidis, T Chaplin, BD Young… - Molecular cancer, 2010 - Springer
Background The human cell cycle transcription factor FOXM1 is known to play a key role in
regulating timely mitotic progression and accurate chromosomal segregation during cell …

[HTML][HTML] MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway

PJ Yue, YY Sun, YH Li, ZM Xu, WN Fu - Cellular Signalling, 2020 - Elsevier
MYCT1 has an inhibitory effect on the migration of laryngeal cancer cells, although the
underlying molecular mechanism remains unknown. In this study, we aimed to explore the …

YY 1 directly suppresses MYCT 1 leading to laryngeal tumorigenesis and progress

SY Qu, YY Sun, YH Li, ZM Xu, WN Fu - Cancer medicine, 2017 - Wiley Online Library
YY 1 is a key transcription factor and plays different roles in various cancers. However, role
and mechanism of YY 1 in laryngeal cancer are still unknown. YY 1 and MYCT 1 mRNA and …

[HTML][HTML] MYCT1-TV, A Novel MYCT1 Transcript, Is Regulated by c-Myc and May Participate in Laryngeal Carcinogenesis

S Fu, Y Guo, H Chen, ZM Xu, GB Qiu, M Zhong… - PLoS …, 2011 - journals.plos.org
Background MYCT1, a putative target of c-Myc, is a novel candidate tumor suppressor gene
cloned from laryngeal squamous cell carcinoma (LSCC). Its transcriptional regulation and …

[HTML][HTML] Overexpression of MYCT1 Inhibits Proliferation and Induces Apoptosis in Human Acute Myeloid Leukemia HL-60 and KG-1a Cells in vitro and in vivo

S Fu, Y Fu, F Chen, Y Hu, B Quan… - Frontiers in …, 2018 - frontiersin.org
MYC target 1 (MYCT1), a direct target gene of c-Myc, is a novel candidate tumor suppressor
gene first cloned from laryngeal squamous cell carcinoma. The downregulation of MYCT1 …

[HTML][HTML] Promoter hypermethylation-induced transcriptional down-regulation of the gene MYCT1in laryngeal squamous cell carcinoma

M Yang, W Li, YY Liu, S Fu, GB Qiu, KL Sun, WN Fu - BMC cancer, 2012 - Springer
Background MYCT1, previously named MTLC, is a novel candidate tumor suppressor gene.
MYCT1 was cloned from laryngeal squamous cell cancer (LSCC) and has been found to be …

[HTML][HTML] MUC15 is an independent prognostic factor that promotes metastases of MYCN non-amplified neuroblastoma

H Guo, WX Zhang, Q Zhang, M Li, HY Wang… - Journal of …, 2023 - ncbi.nlm.nih.gov
Background: Neuroblastoma (NB) is a cancer that arises from neural-crest-derived
sympathoadrenal lineage. Less is known about the pathogenesis and molecular …

Transmembrane domain is crucial to the subcellular localization and function of Myc target 1

S Wu, J Gui, X Yin, Q Pan, X Liu… - Journal of cellular and …, 2016 - Wiley Online Library
Deregulation of c‐MYC occurs in a variety of human cancers. Overexpression of c‐MYC
promotes cell growth, proliferation, apoptosis, transformation and genomic instability. MYC …

[HTML][HTML] Gene signatures in wound tissue as evidenced by molecular profiling in the chick embryo model

F Soulet, WW Kilarski, P Antczak, J Herbert, R Bicknell… - BMC genomics, 2010 - Springer
Background Modern functional genomic approaches may help to better understand the
molecular events involved in tissue morphogenesis and to identify molecular signatures and …