Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions
Transcriptional rates are often estimated by fitting the distribution of mature mRNA numbers
measured using smFISH (single molecule fluorescence in situ hybridization) with the …
measured using smFISH (single molecule fluorescence in situ hybridization) with the …
Coupling gene expression dynamics to cell size dynamics and cell cycle events: Exact and approximate solutions of the extended telegraph model
The standard model describing the fluctuations of mRNA numbers in single cells is the
telegraph model which includes synthesis and degradation of mRNA, and switching of the …
telegraph model which includes synthesis and degradation of mRNA, and switching of the …
Analytical time-dependent distributions for gene expression models with complex promoter switching mechanisms
Classical gene expression models assume exponential switching time distributions between
the active and inactive promoter states. However, recent experiments have shown that many …
the active and inactive promoter states. However, recent experiments have shown that many …
Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures
Cell size is controlled to be within a specific range to support physiological function. To
control their size, cells use diverse mechanisms ranging from 'sizers', in which differences in …
control their size, cells use diverse mechanisms ranging from 'sizers', in which differences in …
[HTML][HTML] Modulation of nuclear and cytoplasmic mRNA fluctuations by time-dependent stimuli: Analytical distributions
T Filatova, N Popović, R Grima - Mathematical biosciences, 2022 - Elsevier
Temporal variation of environmental stimuli leads to changes in gene expression. Since the
latter is noisy and since many reaction events occur between the birth and death of an …
latter is noisy and since many reaction events occur between the birth and death of an …
Threshold-crossing time statistics for size-dependent gene expression in growing cells
C Nieto, KR Ghusinga… - 2022 American …, 2022 - ieeexplore.ieee.org
Many intracellular events trigger upon attaining critical concentrations of their corresponding
regulatory proteins. How cells ensure precision in the timing of these events is a …
regulatory proteins. How cells ensure precision in the timing of these events is a …
[PDF][PDF] Accurate inference of stochastic gene expression from nascent transcript heterogeneity
Transcriptional rates are often estimated by fitting the distribution of mature mRNA numbers
measured using smFISH (single molecule fluorescence in situ hybridization) with the …
measured using smFISH (single molecule fluorescence in situ hybridization) with the …
[PDF][PDF] Accuracy and limitations of extrinsic noise models to describe gene expression in growing cells
The standard model describing the fluctuations of mRNA numbers in single cells is the
telegraph model which includes synthesis and degradation of mRNA, and switching of the …
telegraph model which includes synthesis and degradation of mRNA, and switching of the …
Modeling cell size control under dynamic environments
In nature, cells face changes in environmental conditions that can modify their growth rate. In
these dynamic environments, recent experiments found changes in cell size regulation …
these dynamic environments, recent experiments found changes in cell size regulation …
Threshold-crossing time statistics for gene expression in growing cells
Many intracellular events are triggered by attaining critical concentrations of their
corresponding regulatory proteins. How cells ensure precision in the timing of the protein …
corresponding regulatory proteins. How cells ensure precision in the timing of the protein …