Immuno-neurology is an emerging therapeutic strategy for dementia and neurodegeneration
designed to address immune surveillance failure in the brain. Microglia, as central nervous …

Progranulin (PGRN) deficiency is linked to neurodegenerative diseases including
frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and neuronal ceroid …

Heterozygous loss-of-function mutations in the progranulin gene (GRN) are a major cause of
frontotemporal dementia due to progranulin haploinsufficiency; complete deficiency of …

Hematopoietic stem cell transplantation can deliver therapeutic proteins to the CNS through
donor-derived hematopoietic cells that become microglia-like cells. However, using …

The impact of animal models of neurological disorders remains hotly debated, the main
point of contention being the frequent clinical failure of therapies successfully tested in …

Identification of variants, genes and pathways in synucleinopathies using bioinformatics and
machine learning Eric Yu Department Page 1 Identification of variants, genes and pathways in …

Frontotemporal dementia (FTD) is a leading cause of early-onset dementia and has a
significant socioeconomic burden due to difficulties in diagnosis and delay to diagnosis. FTD …

Background: Various cancer cells share critical physiologic changes that promote malignant
development. Progranulin [PGRN], a growth factor, has major biological impact on several …