[HTML][HTML] CNS delivery of targeted protein degraders
Heterobifunctional small molecule degraders are a subset of targeted protein degraders
(TPDs), consisting of two ligands joined by a linker to induce proteasomal degradation of a …
(TPDs), consisting of two ligands joined by a linker to induce proteasomal degradation of a …
How kelch domain-containing protein 3 distinguishes between the C-end degron of herpesviral protein UL49. 5 and its mutants–Insights from molecular dynamics
MJ Ślusarz - Bioorganic & Medicinal Chemistry, 2024 - Elsevier
The C-terminal residues of proteins can function as degrons recognized by ubiquitin ligases
for proteasomal degradation. Kelch domain-containing protein 3 (KLHDC3) is a substrate …
for proteasomal degradation. Kelch domain-containing protein 3 (KLHDC3) is a substrate …
Mass spectral feature analysis of ubiquitylated peptides provides insights into probing the dark ubiquitylome
RM Edgington, DB Wilburn - bioRxiv, 2024 - biorxiv.org
Ubiquitylation is a structurally and functionally diverse post translational modification that
involves the covalent attachment of the small protein ubiquitin to other protein substrates …
involves the covalent attachment of the small protein ubiquitin to other protein substrates …