Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?
Cognitive impairment is a devastating condition commonly observed with normal aging and
neurodegenerative disorders such as Alzheimer's Disease (AD). Although major efforts to …
neurodegenerative disorders such as Alzheimer's Disease (AD). Although major efforts to …
Platelets induce apoptosis via membrane-bound FasL
RI Schleicher, F Reichenbach, P Kraft… - Blood, The Journal …, 2015 - ashpublications.org
After tissue injury, both wound sealing and apoptosis contribute to restoration of tissue
integrity and functionality. Although the role of platelets (PLTs) for wound closure and …
integrity and functionality. Although the role of platelets (PLTs) for wound closure and …
Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease
N Mykicki, AM Herrmann, N Schwab… - Science translational …, 2016 - science.org
In inflammation-associated progressive neuroinflammatory disorders, such as multiple
sclerosis (MS), inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells cause …
sclerosis (MS), inflammatory infiltrates containing T helper 1 (TH1) and TH17 cells cause …
Expression of brain-derived neurotrophic factor in astrocytes-Beneficial effects of glatiramer acetate in the R6/2 and YAC128 mouse models of Huntington's disease
C Reick, G Ellrichmann, T Tsai, DH Lee, S Wiese… - Experimental …, 2016 - Elsevier
Glatiramer acetate (GA) is a FDA-approved drug which is licensed for the treatment of
relapsing-remitting multiple sclerosis and which may exert neuroprotective effects via brain …
relapsing-remitting multiple sclerosis and which may exert neuroprotective effects via brain …
MMF induces antioxidative and anaplerotic pathways and is neuroprotective in hyperexcitability in vitro
L Gola, L Bierhansl, N Hummel, L Korn… - Free Radical Biology …, 2023 - Elsevier
Hyperexcitability-induced neuronal damage plays a role both in epilepsy as well as in
inflammatory brain diseases such as multiple sclerosis (MS) and as such represents an …
inflammatory brain diseases such as multiple sclerosis (MS) and as such represents an …
[HTML][HTML] Oxidative stress induces neuronal apoptosis through suppressing transcription factor EB phosphorylation at Ser467
Q Su, B Zheng, C Wang, Y Yang, W Luo, S Ma… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: This study determined the role and mechanism of action of transcription
factor EB (TFEB) in H 2 O 2-induced neuronal apoptosis. Methods: SH-SY5Y cells were …
factor EB (TFEB) in H 2 O 2-induced neuronal apoptosis. Methods: SH-SY5Y cells were …
Natalizumab treatment reduces L-selectin (CD62L) in CD4+ T cells
M Spadaro, M Caldano, F Marnetto, A Lugaresi… - Journal of …, 2015 - Springer
Background The purpose of this research was to validate the low expression of L-selectin
(CD62L) in natalizumab (NTZ)-treated patients. CD62L is involved in rolling and …
(CD62L) in natalizumab (NTZ)-treated patients. CD62L is involved in rolling and …
Neuronal Mitochondrial Calcium Uniporter (MCU) Deficiency Is Neuroprotective in Hyperexcitability by Modulation of Metabolic Pathways and ROS Balance
L Bierhansl, L Gola, V Narayanan, A Dik… - Molecular …, 2024 - Springer
Epilepsy is one of the most common neurological disorders in the world. Common epileptic
drugs generally affect ion channels or neurotransmitters and prevent the emergence of …
drugs generally affect ion channels or neurotransmitters and prevent the emergence of …
ALAIN01—Alemtuzumab in autoimmune inflammatory neurodegeneration: mechanisms of action and neuroprotective potential
T Ruck, AM Afzali, KF Lukat, M Eveslage, CC Gross… - BMC neurology, 2016 - Springer
Abstract Background Alemtuzumab (Lemtrada®) is a newly approved therapeutic agent for
relapsing-remitting multiple sclerosis (RRMS). In previous phase II and III clinical trials …
relapsing-remitting multiple sclerosis (RRMS). In previous phase II and III clinical trials …
Glatiramer acetate protects against inflammatory synaptopathy in experimental autoimmune encephalomyelitis
A Gentile, S Rossi, V Studer, C Motta… - Journal of Neuroimmune …, 2013 - Springer
Glutamate-mediated excitotoxicity is supposed to induce neurodegeneration in multiple
sclerosis (MS). Glatiramer acetate (GA) is an immunomodulatory agent used in MS treatment …
sclerosis (MS). Glatiramer acetate (GA) is an immunomodulatory agent used in MS treatment …