In Parkinson's disease (PD), in addition to degeneration of the nigrostriatal dopaminergic
pathway, a variety of neuronal systems are involved, causing multiple neuromediator …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

The tryptophan metabolite kynurenic acid (KYNA) has long been recognized as an NMDA
receptor antagonist. Here, interactions between KYNA and the nicotinic system in the brain …

The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Objective: To assess whether being able to quit smoking is an early marker of Parkinson
disease (PD) onset rather than tobacco being “neuroprotective,” we analyzed information …

Dopamine deficiency, caused by the degeneration of nigrostriatal dopaminergic neurons, is
the cause of the major clinical motor symptoms of Parkinson's disease. These symptoms can …

Background: There are no studies of autonomic function comparing Alzheimer's disease
(AD), vascular dementia (VAD), dementia with Lewy bodies (DLB) and Parkinson's disease …

During the last decade, nicotine has been used increasingly as an aid to smoking cessation
and has been found to be a safe and efficacious treatment for the symptoms of nicotine …

BackgroundDementia with Lewy bodies (DLB) is a common dementia subtype that has only
been recognised in the past decade and that remains widely underdiagnosed. AimsTo …

High-affinity nicotine binding, considered to primarily reflect the presence of CNS α4β2
nicotinic receptor subunits, was examined autoradiographically in brain regions most …