The 'cytokine storm': molecular mechanisms and therapeutic prospects
R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …
Cell death pathways: intricate connections and disease implications
M Kist, D Vucic - The EMBO Journal, 2021 - embopress.org
Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …
different subset of proteins for the activation and execution of their respective pathway (s). In …
Cell death checkpoints in the TNF pathway
J Huyghe, D Priem, MJM Bertrand - Trends in immunology, 2023 - cell.com
Tumor necrosis factor (TNF) plays a central role in orchestrating mammalian inflammatory
responses. It promotes inflammation either directly by inducing inflammatory gene …
responses. It promotes inflammation either directly by inducing inflammatory gene …
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma
IK Kim, MS Diamond, S Yuan, SB Kemp… - Nature …, 2024 - nature.com
Acquired resistance to immunotherapy remains a critical yet incompletely understood
biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma …
biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma …
Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Escaping death: how cancer cells and infected cells resist cell-mediated cytotoxicity
Cytotoxic lymphocytes are critical in our immune defence against cancer and infection.
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …
Crocin molecular signaling pathways at a glance: A comprehensive review
M Boozari, H Hosseinzadeh - Phytotherapy Research, 2022 - Wiley Online Library
Crocin is a hydrophilic carotenoid that is synthesized in the flowers of the Crocus genus.
Numerous in vitro and in vivo research projects have been published about the biological …
Numerous in vitro and in vivo research projects have been published about the biological …
Macrophages in skin wounds: functions and therapeutic potential
SL Sim, S Kumari, S Kaur, K Khosrotehrani - Biomolecules, 2022 - mdpi.com
Macrophages regulate cutaneous wound healing by immune surveillance, tissue repair and
remodelling. The depletion of dermal macrophages during the early and middle stages of …
remodelling. The depletion of dermal macrophages during the early and middle stages of …
Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection
Mycobacterium tuberculosis (Mtb) is the pathogen that causes tuberculosis (TB), a leading
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …
infectious disease of humans worldwide. One of the main histopathological hallmarks of TB …
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling
Necroptosis is a lytic, proinflammatory cell death pathway, which has been implicated in host
defense and, when dysregulated, the pathology of many human diseases. The central …
defense and, when dysregulated, the pathology of many human diseases. The central …