Joint diseases are one of the most common causes of morbidity and disability worldwide.
The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which …

Proteoglycans are vital components of the extracellular matrix in articular cartilage, providing
biomechanical properties crucial for its proper functioning. They are key players in chondral …

Objectives Analysing expression patterns of Krüppel-like factor (KLF) transcription factors in
normal and osteoarthritis (OA) human cartilage, and determining functions and mechanisms …

Immunogenic cell death (ICDs) has gained increasing attention for its significant clinical
efficacy in various diseases. Similarly, more and more attention has been paid in the role of …

Extracellular matrixes (ECMs) are intricate 3-dimensional macromolecular networks of
unique architectures with regulatory roles in cell morphology and functionality. As a dynamic …

Due to the avascular nature of cartilage, it is difficult to heal and regenerate spontaneously
after injury. At present, tissue engineering has become a promising strategy for repairing …

Aim: To investigate whether kaempferol exhibited protective effects on osteoarthritis
chondrocytes by modulating the XIST/miR-130a/STAT3 axis. Methods: qRT-PCR and …

Osteoarthritis (OA) is the most common form of arthritis resulting in joint discomfort and
disability, culminating in decline in life quality. Attention has been drawn in recent years to …

Intervertebral disc (IVD) shows aging and degenerative changes earlier than any other body
connective tissue. Its repair and regeneration provide a considerable challenge in …

Development of OA (OA) is multifactorial and is strongly associated with risk factors such as
aging, trauma, metabolic disorders, and obesity. Metabolic Syndrome (MetS)-associated OA …