Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …
Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
[HTML][HTML] Current research trends of nanomedicines
Owing to the inherent shortcomings of traditional therapeutic drugs in terms of inadequate
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …
therapeutic efficacy and toxicity in clinical treatment, nanomedicine designs have received …
Aminopeptidase N‐Responsive Conjugates with Tunable Charge‐Reversal Properties for Highly Efficient Tumor Accumulation and Penetration
R Sun, Y Zhang, X Lin, Y Piao, T Xie… - Angewandte Chemie …, 2023 - Wiley Online Library
Tumor enzyme‐responsive charge‐reversal carriers can induce efficient transcytosis and
lead to efficient tumor infiltration and potent anticancer efficacy. However, the correlations of …
lead to efficient tumor infiltration and potent anticancer efficacy. However, the correlations of …
Emerging nanotechnological approaches to regulating tumor vasculature for cancer therapy
Abnormal angiogenesis stands for one of the most striking manifestations of malignant
tumor. The pathologically and structurally abnormal tumor vasculature facilitates a hostile …
tumor. The pathologically and structurally abnormal tumor vasculature facilitates a hostile …
Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles
D Zhu, H Yan, Y Zhou, LM Nack, J Liu… - Advanced Drug Delivery …, 2023 - Elsevier
The therapeutic and diagnostic effects of nanoparticles highly depend on the efficiency of
their delivery to targeted tissues, such as tumors. The size of nanoparticles, among other …
their delivery to targeted tissues, such as tumors. The size of nanoparticles, among other …
Screening of Zwitterionic Liposomes with Red Blood Cell‐Hitchhiking and Tumor Cell‐Active Transporting Capability for Efficient Tumor Entrance
The active transport of nanoparticles into the solid tumor through cell transcytosis has shown
great promise in cancer nanomedicine, but it is challenging to develop efficient active …
great promise in cancer nanomedicine, but it is challenging to develop efficient active …
Role of micelle size in cell transcytosis-based tumor extravasation, infiltration, and treatment efficacy
W Fan, J Xiang, Q Wei, Y Tang, Y Piao, S Shao… - Nano Letters, 2023 - ACS Publications
Transcytosis-based active transport of cancer nanomedicine has shown great promise for
enhancing its tumor extravasation and infiltration and antitumor activity, but how the key …
enhancing its tumor extravasation and infiltration and antitumor activity, but how the key …
Transcytosis‐Inducing Multifunctional Albumin Nanomedicines with Deep Penetration Ability for Image‐Guided Solid Tumor Treatment
Transcytosis is an active transcellular transportation pathway that has garnered interest for
overcoming the limited deep penetration of nanomedicines in solid tumors. In this study, a …
overcoming the limited deep penetration of nanomedicines in solid tumors. In this study, a …
Human solid tumors and clinical relevance of the enhanced permeation and retention effect: a 'golden gate'for nanomedicine in preclinical studies?
Nanocarriers passively accumulate in solid tumors through irregular wide fenestrations in
neovasculature and increased retention due to poor lymphatic drainage, a phenomenon …
neovasculature and increased retention due to poor lymphatic drainage, a phenomenon …