Increasingly potent immunosuppressive agents have dramatically reduced the incidence of
rejection of transplanted organs while increasing susceptibility to opportunistic infections …

In the setting of intensive immunosuppression for the management of rejection in solid organ
transplant (SOT) recipients, or graft-versus-host disease (GVHD) in hematopoietic stem cell …

First performed in 1963, lung transplantation is approaching the half-century mark. With
more than 32,000 procedures having been performed worldwide, lung transplantation has …

The ability to successfully transplant solid organs and hematopoietic stem cells represents
one of the landmark medical achievements of the twentieth century. Solid organ …

Background Concerns have been raised about emergence of ganciclovir resistance as a
result of the advent of both routine oral ganciclovir prophylaxis and highly potent immuno …

Nucleoside analogues such as acyclovir and ganciclovir have been the mainstay of therapy
for alphaherpesviruses (herpes simplex virus (HSV) and varicella-zoster virus (VZV)) and …

Background: Obliterative bronchiolitis remains the major limitation to long-term survival after
lung transplantation. A thorough understanding of the factors that confer high risk of …

Cytomegalovirus (CMV) was first isolated from the salivary gland and kidney of two dying
infants with cytomegalic inclusion bodies and reported in 1956 (1). Two other laboratories …

Human cytomegalovirus (HCMV) infections are common and lead to lifelong infections. In
immunocompetent individuals, primary infections are mostly subclinical or they may be …

Background Ganciclovir-resistant (ganR) cytomegalovirus (CMV) is an emerging and
important problem in solid organ transplant (SOT) recipients. Only through direct comparison …