Molecular diagnostics in cancer should provide the highest specificity and sensitivity in
classification, prognostic stratification and early detection. miRNAs could contribute to hitting …

Simple Summary Genome-wide association studies have identified a vast number of cancer
risk-associated loci harboring numerous single nucleotide polymorphisms that regulate …

Introduction• Gene structure and regulation• Target molecules• Role in development• Role in
cancer• Other biological functions• Summary and perspectives The discovery of microRNAs …

Advanced prostate cancers are known to acquire not only invasive capabilities but also
significant resistance to chemotherapy-induced apoptosis. To understand how microRNAs …

miRNAs are some of the most well-characterized regulators of gene expression. Integral to
several physiological processes, their aberrant expression often drives the pathogenesis of …

Micro-RNAs (miRs) are a recently described class of genes, encoding small non-coding
RNA molecules, which primarily act by down-regulating the translation of target mRNAs …

Background: Expression of ABCG2 is normally absent or low in the pancreas, but high in
human pancreatic cancer cells. The mechanism by which ABCG2 is altered in human …

Since their discovery and the advent of RNA interference, microRNAs have drawn enormous
attention because of their ubiquitous involvement in cellular pathways from life to death, from …

Objective—MicroRNAs play a role in atherosclerosis-related diseases, such as
cerebrovascular or cardiovascular disease. However, the effect of miR-146a, miR-149, miR …

BACKGROUND: Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may
alter the processing, transcription, and expression of miRNAs and, thus, may contribute to …