Indoles, especially multisubstituted ones, are privileged scaffolds found widely in natural
products, bioactive molecules, fine chemicals, and organic functional materials. Although …

As a natural flavonoid, kaempferol is widely distributed in natural medicines. Our study was
aimed at analyzing and comparing the pharmacokinetic differences of kaempferol between …

Introduction: Artemisinin (1) is a milestone compound in malaria treatment, and it exhibits a
broad scope of bioactivities. Herein, sequential chemo-reduction and biotransformation of …

Dihydroartemisinin (DHA) is a sesquiterpene endoperoxide with prominent antimalarial
efficacy, which was discovered by Professor Youyou Tu through the reduction of artemisinin …

Dihydroartemisinin (DHA) is a derivative of artemisinin and is toxic to parasites. We used the
Tetrahymena thermophila (T. thermophila) as a model to explore DHA toxicity. Results …

Malaria diseases are caused by Plasmodium, either P. falciparum or non-P. falciparum
requires antimalarial treatment guidelines. Artemisinin-based combination (ACT) therapies …

Phragmanthera regularis is a hemi-parasitic shrub. It is known for treating various health
ailments. The aim of this study was to evaluate the antimicrobial activity, toxicity, and …

Background Malaria is a serious public health concern. Artemisinin and its derivatives are
first-line drugs for the treatment of Plasmodium falciparum malaria. In mammals, artemisinin …