Alteration in microRNA expression governs the nature and timing of cellular fate commitment

D Sengupta, S Kar - ACS Chemical Neuroscience, 2017 - ACS Publications
In the central nervous system, the expression level of transcriptional repressor Hes1 (hairy
and enhancer of split-1) tightly controls the alternative cell fate commitment during …

Dynamics of a miRNA model with two delays

S Nikolov, JV Gonzalez, M Nenov… - Biotechnology & …, 2012 - Taylor & Francis
MicroRNAs are a large class of post-transcriptional regulators of gene expression and they
have important regulatory functions in basic cellular processes. In this paper, mathematical …

Analysis of miRNA regulation suggests an explanation for 'unexpected'increase in target protein levels

SA Gokhale, CJ Gadgil - Molecular BioSystems, 2012 - pubs.rsc.org
MicroRNA (miRNA) has been mostly associated with decrease in target protein expression
levels. Recently,'unexpected'observations of increase in target protein expression attributed …

[HTML][HTML] Slowly produced microRNAs control protein levels

ZL Whichard, AE Motter, PJ Stein, SJ Corey - Journal of Biological …, 2011 - ASBMB
Proteins are the primary agents of function in biological systems, and their levels are critical
control elements, reflecting the interplay between transcription, translation, and protein …

Periodic perturbation of genetic oscillations

VP Zhdanov - Chaos, Solitons & Fractals, 2012 - Elsevier
Kinetics of gene expression may be oscillatory due to the feedbacks between the mRNA,
non-coding RNA and protein synthesis. In complex genetic networks, the kinetic oscillations …

Stability and Hopf bifurcation analysis in a delayed three-node circuit involving interlinked positive and negative feedback loops

G Wang, Z Yang, M Turcotte - Mathematical Biosciences, 2019 - Elsevier
A system involving interlinked positive and negative feedback loops is a flexible motif that
can tune itself in gene regulatory networks. It is well known that time delay is inevitable in …

Stability and Hopf Bifurcation Analysis in a Delayed Myc/E2F/miR‐17‐92 Network Involving Interlinked Positive and Negative Feedback Loops

G Wang, Z Yang - Discrete Dynamics in Nature and Society, 2018 - Wiley Online Library
MiR‐17‐92 plays an important role in regulating the levels of the Myc/E2F protein. In this
paper, we consider a coupling network between Myc/E2F/miR‐17‐92 delayed negative …

Coherence resonance in a noise-driven gene network regulated by small RNA

Y Zhu, J Shen, Y Xu - Theoretical and Applied Mechanics Letters, 2014 - Elsevier
Small RNA has recently drawn more and more attention. In this paper, we concentrate on
the influence of noises on gene network regulated by small RNA using chemical Langevin …

A simple method for incorporating dynamic effects of intronic miRNA mediated regulation

S Gokhale, M Hariharan, SK Brahmachari… - Molecular …, 2012 - pubs.rsc.org
The importance of microRNA (miRNA) in modulating gene expression at the post-
transcriptional level is well known. Such regulation has been shown to influence the …

Hierarchical genetic networks and noncoding RNAs

VP Zhdanov - Chaos: An Interdisciplinary Journal of Nonlinear …, 2010 - pubs.aip.org
In eukaryotic cells, many genes are transcribed into noncoding RNAs. Such RNAs may
associate with mRNAs and inhibit their translation and facilitate degradation. To clarify what …