Neural immunoglobulin superfamily interaction networks
K Zinn, E Özkan - Current opinion in neurobiology, 2017 - Elsevier
Highlights•Mammalian IgSF subfamilies define small interaction networks.•A global
Drosophila IgSF interaction map identifies complex binding networks.•Large networks with …
Drosophila IgSF interaction map identifies complex binding networks.•Large networks with …
Loss of hepatic CEACAM1: a unifying mechanism linking insulin resistance to obesity and non-alcoholic fatty liver disease
G Heinrich, HE Ghadieh, SS Ghanem… - Frontiers in …, 2017 - frontiersin.org
The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …
Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets
Background The development of a safe, effective, reversible, non-hormonal contraceptive
method for men has been an ongoing effort for the past few decades. However, despite …
method for men has been an ongoing effort for the past few decades. However, despite …
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis
HE Ghadieh, L Russo, HT Muturi, SS Ghanem… - Metabolism, 2019 - Elsevier
Background CEACAM1 regulates insulin sensitivity by promoting insulin clearance.
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Forced hepatic overexpression of CEACAM1 curtails diet-induced insulin resistance
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …
Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice
HE Ghadieh, ZN Smiley, MW Kopfman, MG Najjar… - Nutrition & …, 2015 - Springer
Abdominal obesity is a major risk factor for insulin resistance, type 2 diabetes and
cardiovascular diseases. Dietary fat induces insulin resistance in humans and rodents. The …
cardiovascular diseases. Dietary fat induces insulin resistance in humans and rodents. The …
Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice
L Russo, HT Muturi, HE Ghadieh, SS Ghanem… - Diabetologia, 2017 - Springer
Aims/hypothesis The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
Fenofibrate decreases insulin clearance and insulin secretion to maintain insulin sensitivity
SK Ramakrishnan, L Russo, SS Ghanem… - Journal of Biological …, 2016 - ASBMB
High fat diet reduces the expression of CEACAM1 (carcinoembryonic antigen-related cell
adhesion molecule 1), a transmembrane glycoprotein that promotes insulin clearance and …
adhesion molecule 1), a transmembrane glycoprotein that promotes insulin clearance and …
CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo
MM Alshahrani, E Yang, J Yip… - Blood, The Journal …, 2014 - ashpublications.org
Carcinoembryonic antigen–related cell adhesion molecule-2 (CEACAM2) is a cell-surface
glycoprotein expressed on blood, epithelial, and vascular cells. CEACAM2 possesses …
glycoprotein expressed on blood, epithelial, and vascular cells. CEACAM2 possesses …
Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis [S]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …