Obesity, oxidative stress, adipose tissue dysfunction, and the associated health risks: causes and therapeutic strategies

P Manna, SK Jain - Metabolic syndrome and related disorders, 2015 - liebertpub.com
Obesity is gaining acceptance as a serious primary health burden that impairs the quality of
life because of its associated complications, including diabetes, cardiovascular diseases …

What we talk about when we talk about fat

ED Rosen, BM Spiegelman - Cell, 2014 - cell.com
There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

Overview of epidemiology and contribution of obesity to cardiovascular disease

M Bastien, P Poirier, I Lemieux, JP Després - Progress in cardiovascular …, 2014 - Elsevier
The prevalence of obesity has increased worldwide and is a source of concern since the
negative consequences of obesity start as early as in childhood. The most commonly used …

Collagen structure: new tricks from a very old dog

J Bella - Biochemical Journal, 2016 - portlandpress.com
The main features of the triple helical structure of collagen were deduced in the mid-1950s
from fibre X-ray diffraction of tendons. Yet, the resulting models only could offer an average …

Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: basic mechanisms and clinical associations

TP Fitzgibbons, MP Czech - Journal of the American Heart …, 2014 - Am Heart Assoc
It is well established that the cardiovascular (CV) risk of obesity is more strongly associated
with visceral rather than subcutaneous adiposity. 1–3 Anthropometric variables that account …

Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders

S Lehr, S Hartwig, H Sell - PROTEOMICS–Clinical Applications, 2012 - Wiley Online Library
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …

Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus

IAM van den Oever, HG Raterman… - Mediators of …, 2010 - Wiley Online Library
Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular
disease in obesity‐related type 2 diabetes. The imbalance in repair and injury …

Differential role of leptin and adiponectin in cardiovascular system

CM Ghantous, Z Azrak, S Hanache… - International journal …, 2015 - Wiley Online Library
Leptin and adiponectin are differentially expressed adipokines in obesity and cardiovascular
diseases. Leptin levels are directly associated with adipose tissue mass, while adiponectin …

Role of adipokines in cardiovascular disease

WB Lau, K Ohashi, Y Wang, H Ogawa… - Circulation …, 2017 - jstage.jst.go.jp
Cardiovascular disease (CVD) is the greatest cause of death, accounting for nearly one-third
of all deaths worldwide. The increase in obesity rates over 3 decades is widespread and …

M2 macrophages as a potential target for antiatherosclerosis treatment

Y Bi, J Chen, F Hu, J Liu, M Li, L Zhao - Neural plasticity, 2019 - Wiley Online Library
Atherosclerosis is a chronic progressive inflammation course, which could induce life‐
threatening diseases such as stroke and myocardial infarction. Optimal medical treatments …