Le facteur hyperpolarisant provenant de l'endothélium, ou EDHF, est défini comme la
substance non-monoxyde d'azote (NO) et non-prostacycline (PGI2) qui véhicule …

The therapeutic actions of cannabinoids have been known for centuries. In the last 25 years
this area of research has grown exponentially with the discovery of specific cannabinoid …

Intercellular communication in many organs is maintained via intercellular gap junction
channels composed of connexins, a large protein family with a number of isoforms. This gap …

Acute lung injury (ALI), which is associated with a mortality of 30–40%, is attributable to
inflammation that develops rapidly across the lung's vast vascular surface, involving an …

Cannabinoids are a structurally diverse group of mostly lipophilic molecules that bind to
cannabinoid receptors. In fact, endogenous cannabinoids (endocannabinoids) are a class of …

Arachidonic acid (AA) and its metabolites (eicosanoids) represent powerful mediators, used
by organisms to induce and suppress inflammation as a part of the innate response to …

There is a dearth of chemical inhibitors of connexin-mediated intercellular communication.
The advent of short “designer” connexin mimetic peptides has provided new tools to inhibit …

Anandamide (AEA) has vasodilator activity, which can be terminated by cellular re-uptake
and degradation. Here we investigated the presence and regulation of the AEA transporter …

The endocannabinoid anandamide has been reported to affect neuronal cells, immune cells
and smooth muscle cells via either CB1 or CB2 receptors. In endothelial cells, the receptors …

Cannabinoids, the bioactive constituents of the marijuana plant and their synthetic and
endogenous analogs cause not only neurobehavioral, but also cardiovascular effects. The …