Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Myocardial ischemia-reperfusion injury (MIRI) results in the aggravation of myocardial injury
caused by rapid recanalization of the ischemic myocardium. In the past few years, there is a …

The reactive oxygen species‐(ROS‐) induced nod‐like receptor protein‐3 (NLRP3)
inflammasome triggers sterile inflammatory responses and pyroptosis, which is a …

Abstract Treatment options for myocarditis are currently limited. Inhibition of calpains has
been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac injuries, but the …

The nod-like receptor protein-3 (NLRP3)-mediated pyroptosis is involved in kidney
diseases. Thioredoxin interacting protein (TXNIP) directly interacts with NLRP3. This study …

Lacrimal gland inflammation triggers dry eye disease through impaired tear secretion by the
epithelium. As aberrant inflammasome activation occurs in autoimmune disorders including …

The vast majority of cases of infectious cystitis are easily treated, and most patients have no
long-term complications. However, hemorrhagic cystitis is a potentially deadly complication …

Inflammation plays a pivotal role in the ischemia/reperfusion (I/R) injury. Inflammatory
response is initiated by the detection of pathogen-associated molecular patterns and/or …

Myocardial contractile dysfunction in sepsis is associated with the increased morbidity and
mortality. Although the underlying mechanisms of the cardiac depression have not been fully …

Aims: Macrophage (MΦ) infiltration during myocardial infarction (MI) amplifies cardiac
inflammation and remodeling. We investigated whether activation of the NRLP3 …