Fastigial nucleus (FN) is the phylogenetically oldest nucleus in the cerebellum, a classical
subcortical motor coordinator. As one of the ultimate integration stations and outputs of the …

The cerebellar cholinergic system belongs to the third type of afferent nerve fiber system
(after the climbing and mossy fibers), and has important modulatory effects on cerebellar …

Serotonergic psychedelics are emerging therapeutics for psychiatric disorders, yet their
underlying mechanisms of action in the brain remain largely elusive. Here, we developed a …

Guineensine is a dietary N-isobutylamide widely present in black and long pepper (Piper
nigrum and Piper longum) previously shown to inhibit cellular endocannabinoid uptake …

The failure of chemoreflexes, arousal, and/or autoresuscitation to asphyxia may underlie
some sudden infant death syndrome (SIDS) cases. In Part I, we showed that some SIDS …

Cerebellar ataxia, characterized by motor incoordination, postural instability, and gait
abnormality [1–3], greatly affects daily activities and quality of life. Although accumulating …

Abstract Serotonin (5-HT) has been reported to play excitatory effects on respiration by
acting on preBötzinger complex (preBötC) neurons in neonatal or juvenile rodents …

Essential tremor (ET) is a progressive neurological disorder with motor and non-motor
symptoms. It has conclusively been shown that modulation of glutamate receptors could …

Classically, the cerebellum has been thought to play a significant role in motor coordination.
However, a growing body of evidence for novel neural connections between the cerebellum …

Histamine and histamine receptors in the central nervous system actively participate in the
modulation of motor control. In clinic, histamine-related agents have traditionally been used …