Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Autoimmune disease: why and where it occurs | Nature Medicine Skip to main content Thank
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Emerging evidence indicates that CD8+ and CD4+ T-cell immunity is differentially regulated.
Here we have delineated differences and commonalities among antiviral T-cell responses …

At least 20 different chromosomal regions have been linked to type 1 diabetes (T1D)
susceptibility in humans, using genome screening, candidate gene testing, and studies of …

The class II major histocompatibility complex (MHC) glycoproteins HLA-DQ8 and HLA-DQ2
in humans and IA g7 in nonobese diabetic (NOD) mice are the major risk factors for …

We have shown that nanoparticles (NPs) can be used as ligand-multimerization platforms to
activate specific cellular receptors in vivo. Nanoparticles coated with autoimmune disease …

Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen
genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to …

A peptide derived from the insulin B chain contains a major epitope for diabetogenic CD4+ T
cells in the NOD mouse model of type 1 diabetes (T1D). This peptide can fill the binding …

Helper T cell responses that focus the TCR repertoire of responding clones provide
experimental access to the mechanisms of clonal selection in vivo. Using TCRβ chain …

In nonobese diabetic (NOD) mice, two sets of autoreactive CD4+ T cells recognize the B: 9–
23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen …