Inhaled corticosteroids: potency, dose equivalence and therapeutic index

PT Daley‐Yates - British journal of clinical pharmacology, 2015 - Wiley Online Library
Glucocorticosteroids are a group of structurally related molecules that includes natural
hormones and synthetic drugs with a wide range of anti‐inflammatory potencies. For …

[HTML][HTML] Inhaled corticosteroids

PJ Barnes - Pharmaceuticals, 2010 - mdpi.com
Inhaled corticosteroids (ICS) are the most effective controllers of asthma. They suppress
inflammation mainly by switching off multiple activated inflammatory genes through …

The relationship between airways inflammation and asthma severity

R Louis, LCK Lau, AO Bron, AC Roldaan… - American journal of …, 2000 - atsjournals.org
In order to investigate the relationship between airways inflammation and disease severity,
and improve the understanding of persistent asthma, 74 asthmatics, with disease severity …

Efficacy and safety of inhaled corticosteroids: new developments

PJ Barnes, S Pedersen, WW Busse - American journal of respiratory …, 1998 - atsjournals.org
Inhaled corticosteroids have revolutionized the treatment of asthma and have now become
the mainstay of therapy for patients with chronic disease (1). In a supplement to this journal …

Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma: a randomized, controlled trial

K Malmstrom, G Rodriguez-Gomez… - Annals of internal …, 1999 - acpjournals.org
Background: Oral leukotriene receptor antagonists have been shown to have efficacy in
chronic asthma. Objective: To compare the clinical benefit of montelukast, a once-daily oral …

Evolution of dry powder inhaler design, formulation, and performance

SP Newman, WW Busse - Respiratory medicine, 2002 - Elsevier
Many companies are now prioritizing the development of dry powder inhalers (DPIs) above
pressurized formulations of asthma drugs. A well-designed DPI and an appropriate powder …

Acute severe asthma

ER McFadden Jr - American Journal of Respiratory and Critical Care …, 2003 - atsjournals.org
Acute severe asthma remains a major economic and health burden. The natural history of
acute decompensations is one of resolution and only about 0.4% of patients succumb …

Treatment of eosinophilic esophagitis with inhaled corticosteroids

WA Faubion Jr, J Perrault, LJ Burgart… - Journal of pediatric …, 1998 - journals.lww.com
Eosinophilic esophagitis (EE) is a newly described inflammatory lesion characterized by
dense eosinophilic infiltration of the esophagus that occurs in the absence of …

Efficacy of inhaled corticosteroids in asthma

PJ Barnes - Journal of allergy and clinical immunology, 1998 - Elsevier
Inhaled corticosteroids have now become established as first-line therapy for patients with
persistent asthma. Corticosteroids are the only currently available asthma therapy that …

A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma

DJ Evans, DA Taylor, O Zetterstrom… - … England Journal of …, 1997 - Mass Medical Soc
Background Inhaled glucocorticoids and oral theophylline are widely used to treat asthma.
We compared the benefits of adding theophylline to inhaled glucocorticoid with those of …