Background Routine use of whole‐cell pertussis (wP) vaccines was suspended in some
countries in the 1970s and 1980s because of concerns about adverse effects. Following this …

Objective: To assess the efficacy and safety of whole-cell and acellular pertussis vaccines
administered to children singly or within diphtheria, tetanus and pertussis (DTP) vaccines …

To better characterize the transplacental transfer and persistence of pertussis antibodies
and their role in the immune response to vaccine, concentrations of pertussis agglutinins …

Background. The goal of the trial was to determine the efficacy of a multicomponent acellular
pertussis vaccine against Bordetella illnesses in comparison with a whole-cell product and …

Concern over adverse reactions temporally associated with whole cell pertussis vaccine and
advances in the understanding of the Bordetella pertussis organism have led to a new …

A massive diphtheria epidemic in Eastern Europe has resulted in increased anxiety that this
disease could spread to other countries. This fear is realistic because there is a gap in the …

During the past 15 years there have been remarkable increases in our understanding of
Bordetella pertussis and the disease it causes. Indeed, the increase in pertussis-related ci …

Objective.—To evaluate the safety and immunogenicity in adults of several different
concentrations of an acellular pertussis vaccine. Design.—Double-blind, randomized …

The expanded knowledge of the components of Bordetella pertussis has led to the
production of new vaccines consisting of one or more components of the organism. The …

In preparation for a large efficacy trial in Germany, a pilot study was initiated in December
1990. In this study 149 infants were enrolled; with double-blind randomization 75 received …