Antifungal drugs: what brings the future?

R Van Daele, I Spriet, J Wauters, J Maertens… - Medical …, 2019 - academic.oup.com
The high burden and growing prevalence of invasive fungal infections (IFIs), the toxicity and
interactions associated with current antifungal drugs, as well as the increasing resistance …

Targeting pyrimidine metabolism in the era of precision cancer medicine

W Wang, J Cui, H Ma, W Lu, J Huang - Frontiers in oncology, 2021 - frontiersin.org
Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram
metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell …

Effects of nanoplastics and butyl methoxydibenzoylmethane on early zebrafish embryos identified by single-cell RNA sequencing

Y Liu, Y Wang, X Ling, Z Yan, D Wu… - … Science & Technology, 2021 - ACS Publications
Nanoplastics with small particle sizes and high surface area/volume ratios easily absorb
environmental pollutants and affect their bioavailability. In this study, polystyrene nanoplastic …

Microbial transcript and metabolome analysis uncover discrepant metabolic pathways in autotrophic and mixotrophic anammox consortia

Y Feng, Y Zhao, Y Guo, S Liu - Water Research, 2018 - Elsevier
The ability of anammox bacteria to utilize organic matter has drawn extensive attention.
However, the metabolic discrepancies between autotrophic and mixotrophic anammox …

Advances and perspectives in prostate cancer biomarker discovery in the last 5 years through tissue and urine metabolomics

AR Lima, J Pinto, F Amaro, ML Bastos, M Carvalho… - Metabolites, 2021 - mdpi.com
Prostate cancer (PCa) is the second most diagnosed cancer in men worldwide. For its
screening, serum prostate specific antigen (PSA) test has been largely performed over the …

[HTML][HTML] Emerging roles of nucleotide metabolism in cancer development: progress and prospect

J Ma, M Zhong, Y Xiong, Z Gao, Z Wu, Y Liu… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies
have shown that abnormal nucleotide metabolism not only accelerates the development of …

Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives

L Zhang, J Zhang, J Wang, C Ren, P Tang… - European journal of …, 2022 - Elsevier
Human dihydroorotate dehydrogenase (hDHODH) is a flavin-dependent enzyme catalyzing
the fourth step of pyrimidine de novo biosynthesis. Since aberrant pyrimidine metabolism is …

Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities

AD Robinson, ML Eich, S Varambally - Cancer letters, 2020 - Elsevier
Cancer is a disease of uncontrolled cell growth and a major cause of death worldwide. Many
molecular events characterize tumor initiation and progression. Global gene expression …

Metabolic insights into the enhanced nitrogen removal of anammox by montmorillonite at reduced temperature

X Yang, J Zhou, T Huo, Y Lv, J Pan, L Chen… - Chemical Engineering …, 2021 - Elsevier
Anammox is a low-cost and high-efficiency nitrogen removal technology. However,
anammox bacteria are sensitive to realistic temperature variations of municipal wastewater …

[HTML][HTML] Filamentation of metabolic enzymes in Saccharomyces cerevisiae

QJ Shen, H Kassim, Y Huang, H Li, J Zhang… - Journal of genetics and …, 2016 - Elsevier
Compartmentation via filamentation has recently emerged as a novel mechanism for
metabolic regulation. In order to identify filament-forming metabolic enzymes systematically …