ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

Alkaloids are important chemical compounds that serve as a rich source for drug discovery.
Numerous alkaloids screened from medicinal plants and herbs showed antiproliferative and …

Cancer still represents a “nightmare” worldwide, causing annually millions of victims.
Several antiproliferative molecules are currently used as drugs market and offer a …

Lung cancer is the leading cause of death in men and women worldwide, affecting millions
of people. Between the two types of lung cancers, non-small cell lung cancer (NSCLC) is …

Breast cancer heterogeneity allows cells with different phenotypes to co-exist, contributing to
treatment failure and development of drug resistance. In addition, abnormal signal …

Background Indole alkaloids are very promising for potential therapeutic purposes and
appear to be particularly effective against respiratory diseases. Several experimental studies …

Department of Pediatrics, Nippon Medical School, Tokyo, Japan Effective leukemia
treatment is seriously hampered by drug resistance, and the potential role of epigenetic …

Cancer is a neoplastic disease that remains a global challenge with a reported prevalence
that is increasing annually. Though existing drugs can be applied as single or combined …

Abstract Microtubule-targeting agents (MTAs), like taxanes and vinca alkaloids, are tubulin-
binding drugs that are very effective in the treatment of various types of cancers. In cell …

Chemotherapeutic targeting of microtubules has been the standard of care in treating a
variety of malignancies for decades. During mitosis, increased microtubule dynamics are …