Oxidative stress occurs prior to amyloid Aβ plaque formation and tau phosphorylation in Alzheimer's disease: Role of glutathione and metal ions

RG Roy, PK Mandal, JC Maroon - ACS Chemical Neuroscience, 2023 - ACS Publications
Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …

[HTML][HTML] Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: a review

D Zhao, K Yang, H Guo, J Zeng, S Wang, H Xu… - Biomedicine & …, 2023 - Elsevier
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by
massive loss of specific neurons. It is a progressive disabling, severe and fatal complex …

Customized Intranasal Hydrogel Delivering Methylene Blue Ameliorates Cognitive Dysfunction against Alzheimer's Disease

Y Liu, Y Tan, G Cheng, Y Ni, A Xie, X Zhu… - Advanced …, 2024 - Wiley Online Library
The accumulation of hyperphosphorylated tau protein aggregates is a key pathogenic event
in Alzheimer's disease (AD) and induces mitochondrial dysfunction and reactive oxygen …

Recent progress of oxidative stress associated biomarker detection

J Li, L Pan, W Pan, N Li, B Tang - Chemical Communications, 2023 - pubs.rsc.org
Oxidative stress denotes the imbalance between the generation of reactive oxygen species
(ROS) and antioxidant defenses in living organisms, participating in various …

[HTML][HTML] Ginsenoside Rk3 ameliorates Aβ-induced neurotoxicity in APP/PS1 model mice via AMPK signaling pathway

L She, L Xiong, L Li, J Zhang, J Sun, H Wu… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) has become a major public health problem affecting the elderly
population, and there is currently no effective treatment. Although the pathogenesis of AD is …

An NIR-Driven Upconversion/C3N4/CoP Photocatalyst for Efficient Hydrogen Production by Inhibiting Electron–Hole Pair Recombination for Alzheimer's Disease …

K Ge, Z Li, A Wang, Z Bai, X Zhang, X Zheng, Z Liu… - ACS …, 2023 - ACS Publications
Redox imbalance and abnormal amyloid protein (Aβ) buildup are key factors in the etiology
of Alzheimer's disease (AD). As an antioxidant, the hydrogen molecule (H2) has the …

Application of biomarker-derived fluorescent probes for the detection of Alzheimer's disease

H Ding, Z Li, K Luo, Q Gong, X Tian - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of beta-amyloid (Aβ) protein and neurofibrillary tangles in the brain, resulting …

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Y Zhou, C Qian, Y Tang, M Song, T Zhang… - Phytotherapy …, 2023 - Wiley Online Library
Numerous pharmacological effects of quercetin have been illustrated, including
antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant …

Engineered bacterial extracellular vesicles for central nervous system diseases

N Ji, F Wang, M Wang, W Zhang, H Liu, J Su - Journal of Controlled …, 2023 - Elsevier
The prevalence of central nervous system (CNS) diseases is on the rise as the population
ages. The presence of various obstacles, particularly the blood-brain barrier (BBB), poses a …

Monoamine oxidase B inhibitors based on natural privileged scaffolds: A review of systematically structural modification

Y Lv, Z Zheng, R Liu, J Guo, C Zhang, Y Xie - International Journal of …, 2023 - Elsevier
Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …