Neural tube closure: cellular, molecular and biomechanical mechanisms
Neural tube closure has been studied for many decades, across a range of vertebrates, as a
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …
Neural tube defects
NDE Greene, AJ Copp - Annual review of neuroscience, 2014 - annualreviews.org
Neural tube defects (NTDs), including spina bifida and anencephaly, are severe birth
defects of the central nervous system that originate during embryonic development when the …
defects of the central nervous system that originate during embryonic development when the …
Genetic polymorphisms and folate status
M Hiraoka, Y Kagawa - Congenital anomalies, 2017 - Wiley Online Library
Moderate hyperhomocysteinemia‐induced low folate status is an independent risk factor for
cardiovascular disease, dementia, and depression. Folate is an essential cofactor in the one …
cardiovascular disease, dementia, and depression. Folate is an essential cofactor in the one …
Maternal folic acid supplementation mediates offspring health via DNA methylation
HY Liu, SM Liu, YZ Zhang - Reproductive Sciences, 2020 - Springer
The clinical significance of periconceptional folic acid supplementation (FAS) in the
prevention of neonatal neural tube defects (NTDs) has been recognized for decades …
prevention of neonatal neural tube defects (NTDs) has been recognized for decades …
Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders
R Kozyraki, O Cases - Biochimie, 2013 - Elsevier
BACKGROUND: Vitamin B12 (cobalamin) is a cobalt-containing compound synthesized by
bacteria and an essential nutrient in mammals, which take it up from diet. The absorption …
bacteria and an essential nutrient in mammals, which take it up from diet. The absorption …
Nutrition, one-carbon metabolism and neural tube defects: a review
K Li, ML Wahlqvist, D Li - Nutrients, 2016 - mdpi.com
Neural tube defects (NTDs) are a group of severe congenital malformations, induced by the
combined effects of genes and the environment. The most valuable finding so far has been …
combined effects of genes and the environment. The most valuable finding so far has been …
Should vitamin B12 status be considered in assessing risk of neural tube defects?
AM Molloy - Annals of the New York Academy of Sciences, 2018 - Wiley Online Library
There is a strong biological premise for including vitamin B12 with folic acid in strategies to
prevent neural tube defects (NTDs), due to the closely interlinked metabolism of these two …
prevent neural tube defects (NTDs), due to the closely interlinked metabolism of these two …
An update on vitamin B12-related gene polymorphisms and B12 status
Background Vitamin B12 is an essential micronutrient in humans needed for health
maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and …
maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and …
[HTML][HTML] Low serum vitamin B-12 concentrations are prevalent in a cohort of pregnant Canadian women
CE Visentin, SP Masih, L Plumptre, TH Schroder… - The Journal of …, 2016 - Elsevier
Abstract Background: Among Canadian women of reproductive age, 5% and 20% have
serum vitamin B-12 concentrations indicative of deficiency (< 148 pmol/L) and marginal …
serum vitamin B-12 concentrations indicative of deficiency (< 148 pmol/L) and marginal …
One-carbon metabolism and folate transporter genes: Do they factor prominently in the genetic etiology of neural tube defects?
Neural tube defects (NTDs) are a broad class of congenital birth defects that result from the
failure of neural tube closure during neurulation. Folic acid supplementation has been …
failure of neural tube closure during neurulation. Folic acid supplementation has been …