Context Randomized clinical trials have recently examined the benefit of adding docetaxel
or abiraterone to androgen deprivation therapy (ADT) in hormone-naïve advanced prostate …

With increases in the mortality rate and number of patients with prostate cancer (PCa), PCa,
particularly the advanced and metastatic disease, has been the focus of a number of studies …

Abstract Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic enzyme
that mainly represses transcription of target genes via symmetric dimethylation of arginine …

Ginger has many bioactive compounds with pharmacological activities. However, few
studies are known about these bioactive compounds activity in chemoresistant cells. The …

Prostate carcinoma is a highly prevalent biologically and clinically diverse disease,
generally associated with a consistent elevation of prostate-specific antigen levels …

Advancements in research have added several new therapies for castration-resistant
prostate cancer (CRPC), greatly augmenting our ability to treat patients. However, CRPC …

Background: With prostate cancer being the fifth-greatest cause of cancer mortality in 2020,
there is a dire need to expand the available treatment options. Castration-resistant prostate …

Objective To investigate the association between Prostate-Specific Membrane Antigen
(PSMA) expression changes on positron emission tomography–computed tomography …

Background The progression of prostate cancer to castration-resistant prostate cancer
(CRPC) is often a result of somatic alterations in the PI3K/Akt/mTOR (mammalian target of …

Tubulin has been shown to be an effective target for the development of cytotoxic agents
against prostate cancer. Previously, we reported that Lx2-32c is an anti-tubulin agent with …