The NPRTSG has collected data on pediatric KTx since 1994. The registry archives
information from all centers that perform pediatric KTx in Denmark, Finland, Norway, and …

Coronary heart disease (CHD) is the leading cause of death in Western civilizations, in
particular in chronic kidney disease (CKD) patients. Serum total cholesterol and LDL have …

Background There is a perception that kidney transplant recipients transferred from pediatric
centers to adult care have an increased risk of graft loss. It is not clear whether young adults …

Introduction: Sirolimus is a powerful antiproliferative immunosuppressive drug approved for
the prevention of kidney allograft rejection. By its unique mechanism of action, sirolimus …

The last two decades have witnessed a pandemic in antibody development, with over 600
entering clinical studies and a total of 28 approved by the FDA and European Union. The …

Objective Immunosuppressive regimens after renal transplantation usually include a
combination of calcineurin inhibitors, corticosteroids, and a proliferation inhibitor, either …

ABSTRACT​ Introduction: As tolerance is not yet achievable, the kidney-transplanted-
patients have to take on a daily-basis immunosuppressive drugs in order to avoid acute …

Importance of the field: The prevalence of acute renal allograft rejection has decreased
substantially in past decades due to new and more specific immunosuppressive compounds …

There has been considerable interest in the individualization of immunosuppressive
regimens in an attempt to avoid side effects and improve long-term outcomes. Most …

BACKGROUND In Brazil, the National Health System (SUS) is responsible for almost all
renal transplants. SUS protocols recommend using cyclosporine, in association with …