Hormone receptor (HR)‐positive and human epidermal growth factor receptor 2 (HER2)‐
negative breast cancer is defined by the presence of the estrogen receptor and/or the …

Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …

Simple Summary The effectiveness and safety of the anti-cancer agent doxorubicin
(anthracycline group medicine) depend on the metabolism and retention of the drug in the …

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant
disorders associated with an increased risk of benign and malignant intestinal and …

The NCCN Guidelines for Survivorship provide screening, evaluation, and treatment
recommendations for consequences of adult-onset cancer and its treatment, with the goal of …

PURPOSE To determine the sensitivity and specificity of genetic testing criteria for the
detection of germline pathogenic variants in women with breast cancer. MATERIALS AND …

PURPOSE Despite advances in DNA sequencing technology and expanded medical
guidelines, the vast majority of individuals carrying pathogenic variants of common cancer …

Historically, professional society guidelines have recommended limited genetic testing for
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …

Abstract Background Pathogenic germline variants (PGVs) in certain genes are linked to
higher lifetime risk of developing breast cancer and can influence preventive surgery …

PURPOSE Whether germline multigene panel testing (MGPT) should be performed in all
individuals with colorectal cancer (CRC) remains uncertain. Therefore, we aimed to …