Medicine has undergone staggering advancement over the past decades. From the
discovery of DNA to sequencing the human genome, genetics has, and will continue to …

Breast cancer, a multi‐networking heterogeneous disease, has emerged as a serious
impediment to progress in clinical oncology. Although technological advancements and …

Introduction BRCA1 and BRCA2 are the two main genes causing hereditary breast and
ovarian cancer (HBOC). However, thanks to the development of Next Generation …

Abstract Purpose Latin American reports on genetic cancer risk assessments are scarce. In
Chile, current breast cancer (BC) guidelines do not define strategies for germline genetic …

Panel germline testing allows for the efficient detection of deleterious variants for multiple
conditions, but the benefits and harms of identifying these variants are not always well …

Abstract Changes in medical practice are needed to improve the diagnosis of monogenic
forms of selected common diseases. This article seeks to focus attention on the need for …

Simple Summary The Screen Project was initiated in 2017 to offer BRCA1 and BRCA2
genetic screening to all Canadians over the age of 18 who wish to know their mutation …

Abstract Background The American Society of Breast Surgeons released a consensus
statement that genetic testing should be made available to all patients with a personal …

Current methods of next generation sequencing may simultaneously detect multiple
germline breast cancer susceptibility variants. However, it is a challenge to maximize the …

Importance National Comprehensive Cancer Network guidelines currently recommend
germline testing for high-risk genes in selected patients with breast cancer. The clinical utility …