Rare germline pathogenic variants in cancer‐predisposing genes have a high impact and
potential for clinical utility. In the last 30 years, based on evidence of cancer risk associated …

In this commentary, we discuss opportunities to optimize cancer care delivery in the next
decade building from evidence and advancements in the conceptualization and …

Background: BRCA1 and BRCA2 genes are known to increase breast cancer's lifetime risk.
Early identification of women with this inherited risk can potentially reduce the risk of breast …

One of the major global health crises in the contemporary scenario is the rapid increase in
the incidence of the disease of cancer in general with breast cancer in particular affecting …

Background This study aimed to evaluate the impact of rapid genetic testing (RGT) for
BRCA1 and BRCA2 at the time of breast cancer diagnosis on treatment choices. Bilateral …

Individuals with proven hereditary cancer syndrome (HCS) such as BRCA1 and BRCA2
have elevated rates of ovarian, breast, and other cancers. If these high-risk people can be …

Problem definition: Through the laws of inheritance, knowing an individual's genetic status
informs disease risk for family members, but current protocols for deciding whom to …

Introduction Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs
predominantly in children. To find germline genetic variants associated with …

Discussion Indications for BRCA1/2 testing were recommended by considering national
conditions and referring to relevant guidelines and expert consensus.[6, 8, 9, 10, 11, 12] …

Women at risk for hereditary breast and ovarian cancer syndromes are frequently seen in
primary care and gynecology clinics. They present with a distinctive set of clinical and …