[HTML][HTML] Low-molecular-weight thiol transferases in redox regulation and antioxidant defence
MA Tossounian, Y Zhao, BYK Yu, SA Markey… - Redox Biology, 2024 - Elsevier
Abstract Low-molecular-weight (LMW) thiols are produced in all living cells in different forms
and concentrations. Glutathione (GSH), coenzyme A (CoASH), bacillithiol (BSH), mycothiol …
and concentrations. Glutathione (GSH), coenzyme A (CoASH), bacillithiol (BSH), mycothiol …
Coenzyme A biosynthesis: mechanisms of regulation, function and disease
SA Barritt, SE DuBois-Coyne, CC Dibble - Nature Metabolism, 2024 - nature.com
The tricarboxylic acid cycle, nutrient oxidation, histone acetylation and synthesis of lipids,
glycans and haem all require the cofactor coenzyme A (CoA). Although the sources and …
glycans and haem all require the cofactor coenzyme A (CoA). Although the sources and …
Profiling the site of protein CoAlation and coenzyme A stabilization interactions
MA Tossounian, M Baczynska, W Dalton, C Newell… - Antioxidants, 2022 - mdpi.com
Coenzyme A (CoA) is a key cellular metabolite known for its diverse functions in metabolism
and regulation of gene expression. CoA was recently shown to play an important antioxidant …
and regulation of gene expression. CoA was recently shown to play an important antioxidant …
Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer
Y Zhang, G Zhao, L Yu, X Wang, Y Meng, J Mao… - British Journal of …, 2023 - nature.com
Background NME1 has been exploited as a potential translational target for decades.
Substantial efforts have been made to upregulate the expression of NME1 and restore its …
Substantial efforts have been made to upregulate the expression of NME1 and restore its …
Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet
The synthesis of fatty acids from acetyl–coenzyme A (AcCoA) is deregulated in diverse
pathologies, including cancer. Here, we report that fatty acid accumulation is negatively …
pathologies, including cancer. Here, we report that fatty acid accumulation is negatively …
[HTML][HTML] Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A
V Filonenko, I Gout - BBA advances, 2023 - Elsevier
Coenzyme A (CoA) is an essential cofactor in all living cells which plays critical role in
cellular metabolism, the regulation of gene expression and the biosynthesis of major cellular …
cellular metabolism, the regulation of gene expression and the biosynthesis of major cellular …
Bacillus subtilis YtpP and Thioredoxin A Are New Players in the Coenzyme-A-Mediated Defense Mechanism against Cellular Stress
MA Tossounian, M Baczynska, W Dalton… - Antioxidants, 2023 - mdpi.com
Coenzyme A (CoA) is an important cellular metabolite that is critical for metabolic processes
and the regulation of gene expression. Recent discovery of the antioxidant function of CoA …
and the regulation of gene expression. Recent discovery of the antioxidant function of CoA …
PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases
We describe here the molecular basis of the complex formation of PRUNE1 with the tumor
metastasis suppressors NME1 and NME2, two isoforms appertaining to the nucleoside …
metastasis suppressors NME1 and NME2, two isoforms appertaining to the nucleoside …
Assessment of the Anticancer Potentials of the Free and Metal-Organic Framework (UiO-66)–Delivered Phycocyanobilin
Phycocyanin (C-PC) is a constitutive chromoprotein of Arthrospira platensis, which exhibits
promising efficacy against different types of cancer. In this study, we cleaved C-PC's …
promising efficacy against different types of cancer. In this study, we cleaved C-PC's …
Functional mechanism and clinical implications of miR-141 in human cancers
Q Luo, Y Tian, G Qu, S Luo - Cellular Signalling, 2022 - Elsevier
Cancer is caused by the abnormal proliferation of local tissue cells under the control of many
oncogenic factors. MicroRNAs (miRNAs) are a class of evolutionarily conserved …
oncogenic factors. MicroRNAs (miRNAs) are a class of evolutionarily conserved …