[HTML][HTML] Low-molecular-weight thiol transferases in redox regulation and antioxidant defence

MA Tossounian, Y Zhao, BYK Yu, SA Markey… - Redox Biology, 2024 - Elsevier
Abstract Low-molecular-weight (LMW) thiols are produced in all living cells in different forms
and concentrations. Glutathione (GSH), coenzyme A (CoASH), bacillithiol (BSH), mycothiol …

Coenzyme A biosynthesis: mechanisms of regulation, function and disease

SA Barritt, SE DuBois-Coyne, CC Dibble - Nature Metabolism, 2024 - nature.com
The tricarboxylic acid cycle, nutrient oxidation, histone acetylation and synthesis of lipids,
glycans and haem all require the cofactor coenzyme A (CoA). Although the sources and …

Profiling the site of protein CoAlation and coenzyme A stabilization interactions

MA Tossounian, M Baczynska, W Dalton, C Newell… - Antioxidants, 2022 - mdpi.com
Coenzyme A (CoA) is a key cellular metabolite known for its diverse functions in metabolism
and regulation of gene expression. CoA was recently shown to play an important antioxidant …

Heat-shock protein 90α protects NME1 against degradation and suppresses metastasis of breast cancer

Y Zhang, G Zhao, L Yu, X Wang, Y Meng, J Mao… - British Journal of …, 2023 - nature.com
Background NME1 has been exploited as a potential translational target for decades.
Substantial efforts have been made to upregulate the expression of NME1 and restore its …

Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet

D Iuso, I Garcia-Saez, Y Couté, Y Yamaryo-Botté… - Science …, 2023 - science.org
The synthesis of fatty acids from acetyl–coenzyme A (AcCoA) is deregulated in diverse
pathologies, including cancer. Here, we report that fatty acid accumulation is negatively …

[HTML][HTML] Discovery and functional characterisation of protein CoAlation and the antioxidant function of coenzyme A

V Filonenko, I Gout - BBA advances, 2023 - Elsevier
Coenzyme A (CoA) is an essential cofactor in all living cells which plays critical role in
cellular metabolism, the regulation of gene expression and the biosynthesis of major cellular …

Bacillus subtilis YtpP and Thioredoxin A Are New Players in the Coenzyme-A-Mediated Defense Mechanism against Cellular Stress

MA Tossounian, M Baczynska, W Dalton… - Antioxidants, 2023 - mdpi.com
Coenzyme A (CoA) is an important cellular metabolite that is critical for metabolic processes
and the regulation of gene expression. Recent discovery of the antioxidant function of CoA …

PRUNE1 and NME/NDPK family proteins influence energy metabolism and signaling in cancer metastases

V Ferrucci, S Lomada, T Wieland, M Zollo - Cancer and Metastasis …, 2024 - Springer
We describe here the molecular basis of the complex formation of PRUNE1 with the tumor
metastasis suppressors NME1 and NME2, two isoforms appertaining to the nucleoside …

Assessment of the Anticancer Potentials of the Free and Metal-Organic Framework (UiO-66)–Delivered Phycocyanobilin

SA Rashed, SF Hammad, MM Eldakak, IA Khalil… - Journal of …, 2023 - Elsevier
Phycocyanin (C-PC) is a constitutive chromoprotein of Arthrospira platensis, which exhibits
promising efficacy against different types of cancer. In this study, we cleaved C-PC's …

Functional mechanism and clinical implications of miR-141 in human cancers

Q Luo, Y Tian, G Qu, S Luo - Cellular Signalling, 2022 - Elsevier
Cancer is caused by the abnormal proliferation of local tissue cells under the control of many
oncogenic factors. MicroRNAs (miRNAs) are a class of evolutionarily conserved …