The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …

Simple Summary Vincristine is a vinca alkaloid naturally occurring in Catharanthus roseus. It
belongs to antimitotic compounds, which arrest the cell cycle via disrupting microtubule …

Multidrug resistance (MDR) seriously limits the clinical application of chemotherapy. A
mechanism underlying MDR is the overexpression of efflux transporters associated with …

Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase
in cancer cases observed in the elderly population, as well as in children and adolescents …

The co-administration of anticancer drugs and P-glycoprotein (P-gp) inhibitors was a
treatment strategy to surmount multidrug resistance (MDR) in anticancer chemotherapy. In …

Targeted inhibition of a drug efflux transporter P-glycoprotein (P-gp) is an important strategy
to reverse multidrug resistance in cancer chemotherapy. In this study, a rationally structural …

Natural macrocycles have shown impressive activity to overcome P-glycoprotein (P-gp)-
mediated multidrug resistance (MDR). However, the total synthesis and structural …

A proposed strategy to overcome multidrug resistance (MDR) of anticancer drugs in
chemotherapy is to disable the efflux function of P-glycoprotein (P-gp). In this study, based …

A series of 1 H-benzo [f] chromene moieties (4a–z) were synthesised under Ultrasonic
irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray …

Abstract P-glycoprotein (P-gp) is an important factor leading to multidrug resistance (MDR)
in cancer treatment. The co-administration of anticancer drugs and P-gp inhibitors has been …