Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …

The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …

Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues.
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …

Adenosine receptors (AR) are a family of G-protein coupled receptors, comprised of four
members, named A 1, A 2A, A 2B, and A 3 receptors, found widely distributed in almost all …

Polymorphonuclear cells (PMNs) control Streptococcus pneumoniae (pneumococcus)
infection through various antimicrobial activities. We previously found that reactive oxygen …

Epilepsy is one of the most common and disabling chronic neurological diseases affecting
people of all ages. Major challenges of epilepsy management include the persistently high …

Ischemic heart diseases (IHD) are the leading cause of death worldwide. Although the
principal form of treatment of IHD is myocardial reperfusion, the recovery of coronary blood …

Elderly individuals are at increased risk of life-threatening pulmonary infections. Neutrophils
are a key determinant of the disease course of pathogen-induced pneumonia. Optimal host …