Immune checkpoint blockade, which blocks inhibitory signals of T cell activation, has shown
tremendous success in treating cancer, although success still remains limited to a fraction of …

ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the
endoplasmic reticulum that is essential for establishing a hierarchical immune response …

Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of
protein-coding genes in non-canonical reading frames and translation of allegedly non …

Chimeric antigen receptor (CAR) T cell therapy is a promising clinical approach for reducing
tumor progression and prolonging patient survival. However, improvements in both the …

MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell
immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and …

Adaptive immunity is shaped by a selection of peptides presented on major
histocompatibility complex class I (MHC I) molecules. The chaperones Tapasin (Tsn) and …

Central to CD8+ T cell–mediated immunity is the recognition of peptide–major
histocompatibility complex class I (p–MHC I) proteins displayed by antigen-presenting cells …

Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based
epitopes to CD8+ T cells. DCs process internalized protein antigens into peptides that enter …

ATP-binding cassette (ABC) transporters are found in all domains of life and constitute one
of the largest protein superfamilies. ABC transporters harness the energy of ATP binding …