Abstract Purpose of Review Prognosis of patients with advanced melanoma is dismal with a
median overall survival of about 8 months and 5-year overall survival from a diagnosis of …

Melanoma is one of the most lethal and malignant cancers and its incidence is increasing
worldwide, and Japan is not an exception. Although there are numerous therapeutic options …

Dopamine's ability to oxidize to aminochrome explains why this molecule may be a
neurotoxic compound that induces toxicity in both cell lines and animal models …

Background and aims With the development of novel therapies for advanced malignant
melanoma (MM), biomarkers that can accurately reflect the progression of MM are needed …

This review provides an overview of the current understanding of the ontogeny and biology
of melanoma stem cells in cutaneous malignant melanoma. This article also summarizes …

Early diagnosis of malignant melanoma is critical for effective treatment and reduced patient
mortality. However, current clinical and histological variables show limited accuracy in …

Background It is often difficult to accurately predict how a melanoma will progress because
melanomas can be so diverse in their genetic and histological makeup. Objective We sought …

Anorectal malignant melanoma (ARMM) is extremely rare and generally lethal, irrespective
of the treatment administered. The disease is often diagnosed late, metastases being …

Purpose: With the recent developments in novel molecular targeted therapy such as immune-
checkpoint blockades, serine/threonine-protein kinase B-Raf, and mitogen-activated protein …

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon
adducts formation with glutathione. Since its discovery over a century ago, most of the …