Sepsis was first described by the ancient Greek physicians over 2000 years ago. The
pathophysiology of the disease, however, is still not fully understood and hence the mortality …

Sepsis is a life-threatening medical condition, affecting approximately 26 million people
worldwide every year. The disease is a continuum, marked by dysregulated inflammation …

Purpose To determine the trends of infection sites and outcome of sepsis using a national
population-based database. Materials and methods Using the Nationwide Inpatient Sample …

Sepsis remains a critical global health issue, demanding novel therapeutic strategies.
Traditional immunomodulation treatments such as corticosteroids, specific modifiers of …

Sepsis and septic shock are common in critically ill patients and are among the leading
causes of morbidity and mortality despite efforts to improve early diagnosis and to streamline …

Background and Purpose Immunosuppression is the predominant cause of mortality for
sepsis because of failure to eradicate pathogens. No effective and specific drugs capable of …

Objectives: To explore the characteristics of cytokine storm in patients with septic shock after
abdominal surgery, examine its relationship with clinical data, and determine intervention …

Tofacitinib, a janus kinase inhibitor, is a novel immunosuppressive drug for treatment of
rheumatoid arthritis (RA). Septic arthritis (SA) and sepsis caused by Staphylococcus aureus …

Despite the fact that many therapeutic strategies have been adopted to delay the
development of sepsis, sepsis remains one of the leading causes of death in noncoronary …

Monocytes and macrophages participate in both pro-and anti-inflammatory responses
during sepsis. Integrins are the cell adhesion receptors that mediate leukocyte migration and …