Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

The transition from normal to chronic pain is believed to involve alterations in several brain
areas that participate in the perception of pain. These plastic changes are then responsible …

The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …

Chronic pain is a critical clinical problem with an increasing prevalence. However, there are
limited effective prevention measures and treatments for chronic pain. Astrocytes are the …

Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in
isolation from co-occurring cognitive and emotional features in patients. In this study, we …

BACKGROUND Primary dysmenorrhea, or painful menstruation in the absence of pelvic
pathology, is a common, and often debilitating, gynecological condition that affects between …

The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this
Review, we discuss increasing evidence from rodent studies that ACC activation contributes …

Background Chronic pain conditions impose significant burdens worldwide.
Pharmacological treatments like opioids have limitations. Non-invasive non …

Over the past three decades, insights into the role of the cerebellum in emotional processing
have substantially increased. Indeed, methodological refinements in cerebellar lesion …