Emodin: a review of its pharmacology, toxicity and pharmacokinetics

X Dong, J Fu, X Yin, S Cao, X Li, L Lin… - Phytotherapy …, 2016 - Wiley Online Library
Emodin is a natural anthraquinone derivative that occurs in many widely used Chinese
medicinal herbs, such as Rheum palmatum, Polygonum cuspidatum and Polygonum …

Emodin-A natural anthraquinone derivative with diverse pharmacological activities

RB Semwal, DK Semwal, S Combrinck, A Viljoen - Phytochemistry, 2021 - Elsevier
Abstract Emodin (1, 3, 8-trihydroxy-6-methyl-anthraquinone) is a natural anthraquinone
derivative that is present in numerous globally renowned herbal medicines. It is recognised …

[HTML][HTML] Is emodin with anticancer effects completely innocent? Two sides of the coin

EK Akkol, II Tatlı, GŞ Karatoprak, OT Ağar, Ç Yücel… - Cancers, 2021 - mdpi.com
Simple Summary For cancer treatment, which is one of the most common and serious
diseases of our day, miraculous secondary compounds of natural resources, which cannot …

[HTML][HTML] Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription

G Zou, X Zhang, L Wang, X Li, T Xie, J Zhao, J Yan… - Theranostics, 2020 - ncbi.nlm.nih.gov
Anti-angiogenesis is an important and promising strategy in cancer therapy. However, the
current methods using anti-vascular endothelial growth factor A (VEGFA) antibodies or …

[HTML][HTML] The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers

Q Zhang, WW Chen, X Sun, D Qian… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Cancers are generally recognized as the leading cause of death and a predominant barrier
to prolonging life expectancy in both developed and developing countries. Emodin is a …

Caspase-9 as a therapeutic target for treating cancer

B Kim, SK Srivastava, SH Kim - Expert Opinion on Therapeutic …, 2015 - Taylor & Francis
Introduction: Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial
apoptotic pathway, which is activated at multi-protein activation platforms. Its activation is …

An overview of natural plant products in the treatment of hepatocellular carcinoma

D Rawat, S Shrivastava, RA Naik… - Anti-Cancer Agents …, 2018 - ingentaconnect.com
Background: Liver cancer is the fifth most commonly diagnosed cancer and the second
leading cause of cancer-related deaths worldwide. Among the liver cancers, hepatocellular …

Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition

X Pang, L Shao, X Nie, H Yan, C Li, AJ Yeo… - International …, 2021 - Elsevier
Silicosis is a fatal pulmonary disease caused by the inhalation of silica dust, and
characterized by inflammation and fibrosis of the lung, with no effective treatment to date …

[HTML][HTML] Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells

PC Thacker, D Karunagaran - PloS one, 2015 - journals.plos.org
Cervical cancer is the major cause of cancer related deaths in women, especially in
developing countries and Human Papilloma Virus infection in conjunction with multiple …

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes

X Zheng, S Yang, R Zhang, S Wang, G Li… - Drug Design …, 2019 - Taylor & Francis
Background Emodin, a major component of Polygonum multiflorum (PM), has been reported
to exert both protective and toxic effects in several cell types. However, the effects and …