Multimodal biomedical AI

JN Acosta, GJ Falcone, P Rajpurkar, EJ Topol - Nature Medicine, 2022 - nature.com
The increasing availability of biomedical data from large biobanks, electronic health records,
medical imaging, wearable and ambient biosensors, and the lower cost of genome and …

Algorithmic fairness in artificial intelligence for medicine and healthcare

RJ Chen, JJ Wang, DFK Williamson, TY Chen… - Nature biomedical …, 2023 - nature.com
In healthcare, the development and deployment of insufficiently fair systems of artificial
intelligence (AI) can undermine the delivery of equitable care. Assessments of AI models …

Scaling vision transformers to gigapixel images via hierarchical self-supervised learning

RJ Chen, C Chen, Y Li, TY Chen… - Proceedings of the …, 2022 - openaccess.thecvf.com
Abstract Vision Transformers (ViTs) and their multi-scale and hierarchical variations have
been successful at capturing image representations but their use has been generally …

Artificial intelligence in histopathology: enhancing cancer research and clinical oncology

A Shmatko, N Ghaffari Laleh, M Gerstung, JN Kather - Nature cancer, 2022 - nature.com
Artificial intelligence (AI) methods have multiplied our capabilities to extract quantitative
information from digital histopathology images. AI is expected to reduce workload for human …

Federated learning for predicting histological response to neoadjuvant chemotherapy in triple-negative breast cancer

J Ogier du Terrail, A Leopold, C Joly, C Béguier… - Nature medicine, 2023 - nature.com
Triple-negative breast cancer (TNBC) is a rare cancer, characterized by high metastatic
potential and poor prognosis, and has limited treatment options. The current standard of …

The impact of site-specific digital histology signatures on deep learning model accuracy and bias

FM Howard, J Dolezal, S Kochanny, J Schulte… - Nature …, 2021 - nature.com
Abstract The Cancer Genome Atlas (TCGA) is one of the largest biorepositories of digital
histology. Deep learning (DL) models have been trained on TCGA to predict numerous …

Swarm learning for decentralized artificial intelligence in cancer histopathology

OL Saldanha, P Quirke, NP West, JA James… - Nature medicine, 2022 - nature.com
Artificial intelligence (AI) can predict the presence of molecular alterations directly from
routine histopathology slides. However, training robust AI systems requires large datasets …

Artificial intelligence-based multi-omics analysis fuels cancer precision medicine

X He, X Liu, F Zuo, H Shi, J Jing - Seminars in Cancer Biology, 2023 - Elsevier
With biotechnological advancements, innovative omics technologies are constantly
emerging that have enabled researchers to access multi-layer information from the genome …

Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology

NG Laleh, HS Muti, CML Loeffler, A Echle… - Medical image …, 2022 - Elsevier
Artificial intelligence (AI) can extract visual information from histopathological slides and
yield biological insight and clinical biomarkers. Whole slide images are cut into thousands of …

Pan-cancer integrative histology-genomic analysis via multimodal deep learning

RJ Chen, MY Lu, DFK Williamson, TY Chen, J Lipkova… - Cancer Cell, 2022 - cell.com
The rapidly emerging field of computational pathology has demonstrated promise in
developing objective prognostic models from histology images. However, most prognostic …