Glial Cells of the Central Nervous System: A Potential Target in Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Y Lao, Z Li, Y Bai, W Li, J Wang, Y Wang… - Pain Research and …, 2023 - Wiley Online Library
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the most common
diseases of the male urological system while the etiology and treatment of CP/CPPS remain …

Blocking of NF‑kB/p38 MAPK pathways mitigates oligodendrocyte pathology in a model of neonatal white matter injury

M Al‑Griw, M Salter, I Wood - Acta Neurobiologiae Experimentalis, 2022 - ane.pl
Reactive gliosis and inflammation are risk factors for white matter injury (WMI) development,
which are correlated with the development of many neurodevelopmental deficits with no …

[HTML][HTML] The Danish Pain Research Biobank (DANPAIN-Biobank): a collection of blood, cerebrospinal fluid, and clinical data for the study of neuroimmune and glia …

MR Blichfeldt-Eckhardt, WCP Mortensen… - Annals of …, 2023 - ncbi.nlm.nih.gov
Background Chronic pain is a major health problem worldwide but the limited knowledge of
its underlying pathophysiology impairs the opportunities for diagnostics and treatment …

[PDF][PDF] Assessment of analgesic effects of different initial doses of transdermal buprenorphine in the treatment of chronic pain in the elderly diagnosed with …

M Widenka, W Leppert - J Physiol Pharmacol, 2020 - jpp.krakow.pl
The aim of the study was to evaluate analgesia, adverse effects, and quality of life of elderly
patients diagnosed with osteoarthritis during treatment with different initial doses of …

Brain-Derived Neurotrophic Factor, Nociception, and Pain

A Merighi - Biomolecules, 2024 - mdpi.com
This article examines the involvement of the brain-derived neurotrophic factor (BDNF) in the
control of nociception and pain. BDNF, a neurotrophin known for its essential role in …

Sphingoid Bases Regulate the Sigma-1 Receptor—Sphingosine and N,N'-Dimethylsphingosine Are Endogenous Agonists

J Li, KA Satyshur, LW Guo, AE Ruoho - International Journal of Molecular …, 2023 - mdpi.com
Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in
mammalian cell membranes. Endogenous compounds that regulate the S1R are important …

Molecular pathway of pancreatic cancer‐associated neuropathic pain

SS Giri, AS Tripathi, P Erkekoğlu… - Journal of Biochemical …, 2024 - Wiley Online Library
The pancreas is a heterocrine gland that has both exocrine and endocrine parts. Most
pancreatic cancer begins in the cells that line the ducts of the pancreas and is called …

Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

Y Chen, Y Wei, J Liu, T Zhu, C Zhou… - Neural Regeneration …, 2024 - journals.lww.com
Glial cells play crucial roles in regulating physiological and pathological functions, including
sensation, the response to infection and acute injury, and chronic neurodegenerative …

[PDF][PDF] The therapeutic effects of the peptidyl-prolyl cis/trans isomerase Pin1 inhibitor juglone on animal-model experimental autoimmune encephalomyelitis

ZZ Ge, YB Wu, ZY Xue, K Zhang, RX Zhang - J. Physiol. Pharmacol, 2021 - jpp.krakow.pl
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). There is currently no satisfactory treatment for this disease. Pin1 is …

Single-nucleus transcriptomic analysis reveals divergence of glial cells in peripheral somatosensory system between human and mouse

D Zhang, Y Wei, J Liu, Y Yang, M Ou, Y Chen, J Shen… - bioRxiv, 2022 - biorxiv.org
Glial cells play a crucial role in regulating physiological and pathological functions, such as
sensation, infections, acute injuries, and chronic neurodegenerative disorders. Glial cells …