The regulatory role of actin cytoskeleton on mitochondrial function is a growing research
field, but the underlying molecular mechanisms remain poorly understood. Specific actin …

Peripheral neuropathy, which is the result of nerve damage from lesions or disease,
continues to be a major health concern due to the common manifestation of neuropathic …

The role of cyclin-dependent kinases (CDKs) that are ubiquitously expressed in the adult
nervous system remains unclear. Cdk12 is enriched in terminally differentiated neurons …

Dynamic assembly and disassembly of actin proteins play a key role in the cytoskeleton, but
the cellular functions of actin are not only restricted to the cytoplasmic compartment. Recent …

Actin cytoskeletal dynamics drive cellular shape changes, linking numerous cell functions to
physiological and pathological cues. Mutations in actin regulators that are differentially …

The regulation of gene expression is a critical process for establishing and maintaining
cellular identity. Gene expression is controlled through a chromatin‐based mechanism in …

Background Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are
seed cells that can be used for alternative treatment of myocardial damage. However, their …

Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …

In the cell nucleus, actin participates in numerous essential processes. Actin is involved in
chromatin as part of specific ATP-dependent chromatin remodeling complexes and …

Abnormal mechanical loading of articular cartilage is still considered an important
pathogenic factor for osteoarthritis (OA). The occurrence and development of OA are …