Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

There is a huge need for novel therapeutic and preventative approaches to Alzheimer's
disease (AD) and neuroinflammation seems to be one of the most fascinating solutions. The …

Autism spectrum disorder (ASD) is a neurodevelopmental disease that is characterized by a
deficit in social interactions and communication, as well as repetitive and restrictive …

Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …

Microglia, brain resident immune cells, modulate development, activity, and plasticity of the
central nervous system. Mechanistically implicated in numerous neurological pathologies …

Various age-related diseases involve systemic inflammation, ie a stereotyped series of acute
immune system responses, and aging itself is commonly associated with low-grade …

Background The natural compound asperosaponin VI has shown potential as an
antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to …

Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

Huntington's disease (HD) is a neurodegenerative genetic disorder caused by a CAG repeat
expansion in the huntingtin gene. HD causes motor, cognitive, and behavioral dysfunction …