In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to
bacterial plasmids where they function to mediate the maintenance and stability of usually …

Bacteria depend on two-component systems to detect and respond to threats. Simple
pathways comprise a single sensor kinase (SK) that detects a signal and activates a …

Cultured Myxococcota are predominantly aerobic soil inhabitants, characterized by their
highly coordinated predation and cellular differentiation capacities. Little is currently known …

The bacterium Myxococcus xanthus undergoes multicellular development when starved.
Thousands of cells build mounds in which some differentiate into spores. This remarkable …

Cyclic AMP (cAMP) is a ubiquitous second messenger synthesized by most living
organisms. In bacteria, it plays highly diverse roles in metabolism, host colonization, motility …

Myxococcus xanthus is an environmental bacterium that displays a complex life cycle that
includes motility, predation, multicellular fruiting body development, and sporulation. Given …

The study of natural products is entering a renaissance, driven by the discovery that the
majority of bacterial secondary metabolites are not produced under standard laboratory …

Myxobacteria are fascinating and complex microbes. They prey upon other members of the
soil microbiome by secreting antimicrobial proteins and metabolites, and will undergo …

To accurately identify the genes and pathways involved in the initiation of the Myxococcus
xanthus multicellular developmental program, we have previously reported a method of …

Starvation induces cell aggregation in the soil bacterium Myxococcus xanthus, followed by
formation of fruiting bodies packed with myxospores. Sporulation in the absence of fruiting …